Acarbose promotes remission of both early and late dumping syndromes in post-bariatric patients

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dc.contributor.authorCadegiani, Flavio A. [UNIFESP]
dc.contributor.authorSilva, Osvalmir Sa
dc.date.accessioned2019-01-21T10:29:41Z
dc.date.available2019-01-21T10:29:41Z
dc.date.issued2016
dc.description.abstractObjective: Acarbose is a glucosidase inhibitor that slows carbohydrate digestion. It could thus be effective to promote remission of dumping syndrome (DS). Previous studies associating acarbose and late dumping, although not early dumping, have been reported. Herein, we aimed to evaluate the role of acarbose in dumping syndrome prevention and treatment and in resistive exercises resistance in bariatric subjects. Methods: Bariatric patients with DS and complete adherence to diet plan and resistive exercises were included (n=25). Number of early and late episodes, self-referred intensity of each episode, and ability to increase intensity of resistive exercise were evaluated, on a 0-10 scale. Acarbose was administered orally (50 mg) for 6 months, 4-5 times a day before meals. Results: Acarbose administration was associated with a decrease in the number of early (2.18-0.31) and late (2.79-0.12) episodes per week and intensity of each episode (6.10-1.65) and an increase in the ability to perform resistive exercises (3.03-7.12). Complete remission of DS was seen in 21 patients (84%), which persisted for 6 months with the use of acarbose. Conclusion: Acarbose prevented dumping in almost all studied subjects and helped improve exercise capacity.en
dc.description.affiliationDivision of Endocrinology and Metabolism, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP
dc.description.affiliationCorpometria Institute, an Obesity and Endocrinology Center, Brasilia, DF, Brazil
dc.description.affiliationUnifespDivision of Endocrinology and Metabolism, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, R Pedro de Toledo 781, BR-04039032 Sao Paulo, SP, Brazil.
dc.description.sourceWeb of Science
dc.format.extent443-446
dc.identifierhttps://doi.org/10.2147/DMSO.S123244
dc.identifier.citationDiabetes Metabolic Syndrome And Obesity-Targets And Therapy. Albany, v. 9, p. 443-446, 2016.
dc.identifier.doi10.2147/DMSO.S123244
dc.identifier.fileWOS000389895400001.pdf
dc.identifier.issn1178-7007
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49329
dc.identifier.wosWOS:000389895400001
dc.language.isoeng
dc.publisherCzech Acad Sci, Inst Entomology
dc.relation.ispartofDiabetes Metabolic Syndrome And Obesity-Targets And Therapy
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDumping Syndromeen
dc.subjectBariatric Surgeryen
dc.subjectPost-Bariatricen
dc.subjectObesityGastric Bypassen
dc.subjectHypoglycemiaen
dc.subjectDiagnosisen
dc.subjectPathophysiologyen
dc.subjectOctreotideen
dc.subjectSurgeryen
dc.subjectTherapyen
dc.titleAcarbose promotes remission of both early and late dumping syndromes in post-bariatric patientsen
dc.typeinfo:eu-repo/semantics/article
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