Does mobilization for autologous stem cell transplantation damage stromal layer formation?

Página do item simplificado
dc.contributor.authorSchimieguel, Dulce Marta [UNIFESP]
dc.contributor.authorDominato, Juliana Augusta Albieri [UNIFESP]
dc.contributor.authorZattar, Karin Cecyn [UNIFESP]
dc.contributor.authorRegis Silva, Maria Regina [UNIFESP]
dc.contributor.authorSouza, Marlon Knabben de [UNIFESP]
dc.contributor.authorNader, Helena Bonciani [UNIFESP]
dc.contributor.authorBorelli, Primavera
dc.contributor.authorRodrigues de Oliveira, Jose Salvador [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T13:52:26Z
dc.date.available2016-01-24T13:52:26Z
dc.date.issued2009-04-01
dc.description.abstractAutologous hematopoietic stem cell transplantation (HSCT) has proved efficient to treat hematological malignancies. However, some patients fail to mobilize HSCs. It is known that the microenvironment may undergo damage after allogeneic HSCT. However little is known about how chemotherapy and growth factors contribute to this damage. We studied the stromal layer formation(SLF) and velocity before and after HSC mobilization, through long-term bone marrow culture from 22 patients and 10 healthy donors. Patients' SLF was similar at pre- (12/22)and post-mobilization (9/20), however for controls this occurred more at pre- mobilization (9/10; p=0.03). SLF velocity was higher at pre than post-mobilization in both groups. Leukemias and multiple myeloma showed faster growth of SLF than lymphomas at post-mobilization, the latter being similar to controls. These findings could be explained by less uncommitted HSC in controls than patients at post-mobilization. Control HSCs may migrate more in response to mobilization, resulting in a reduced population by those cells.en
dc.description.affiliationUniversidade Federal de São Paulo, Discipline Hematol & Hemotherapy, Dept Med, BR-04039002 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biochem, BR-04039002 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Discipline Pathol Res, BR-04039002 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Pharmaceut Sci, Dept Clin & Toxicol Anal, Expt Hematol Lab, BR-05508 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Discipline Hematol & Hemotherapy, Dept Med, BR-04039002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biochem, BR-04039002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Discipline Pathol Res, BR-04039002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 02/0999-4
dc.description.sponsorshipIDFAPESP: 02/010290-1
dc.format.extent76-83
dc.identifierhttp://dx.doi.org/10.1179/102453309X385232
dc.identifier.citationHematology. Leeds: Maney Publishing, v. 14, n. 2, p. 76-83, 2009.
dc.identifier.doi10.1179/102453309X385232
dc.identifier.issn1024-5332
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31449
dc.identifier.wosWOS:000268174700003
dc.language.isoeng
dc.publisherManey Publishing
dc.relation.ispartofHematology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAutologous stem cell transplantationen
dc.subjectlong-term bone marrow cultureen
dc.subjectmobilizationen
dc.subjecthematopoiesisen
dc.titleDoes mobilization for autologous stem cell transplantation damage stromal layer formation?en
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
Em verificação - Geral