Microbiota abnormalities and the therapeutic potential of probiotics in the treatment of mood disorders

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dc.citation.issue7
dc.citation.volume28
dc.contributor.authorRios, Adiel C. [UNIFESP]
dc.contributor.authorMaurya, Pawan Kumar [UNIFESP]
dc.contributor.authorPedrini, Mariana [UNIFESP]
dc.contributor.authorZeni-Graiff, Maiara [UNIFESP]
dc.contributor.authorAsevedo, Elson [UNIFESP]
dc.contributor.authorMansur, Rodrigo B.
dc.contributor.authorWieck, Andrea
dc.contributor.authorGrassi-Oliveira, Rodrigo
dc.contributor.authorMcIntyre, Roger S.
dc.contributor.authorHayashi, Mirian A. F. [UNIFESP]
dc.contributor.authorBrietzke, Elisa [UNIFESP]
dc.coverageBerlin
dc.date.accessioned2020-08-04T13:40:07Z
dc.date.available2020-08-04T13:40:07Z
dc.date.issued2017
dc.description.abstractMajor depressive disorder (MDD) and bipolar disorder (BD) are among the leading causes of burden and disability worldwide. Despite intensified research efforts to improve the treatment options and remission rates in mood disorders, no disease modifying treatment exists for these disorders. Accumulating evidence implicates the involvement of the gut microbiota in processes relevant to etiopathology of central nervous system-based disorders. The objective of this article was to critically evaluate the evidence supporting the link between gastrointestinal microbiota and mood disorders and to discuss the potential benefits of using probiotics in the treatment of MDD and BD. The concept of psychobiotics, which is bacterial-based interventions with mental health benefit, is emerging in the field. On the other hand, while probiotics might potentially represent a significant advance, specific roles of microbiota in the pathophysiology of mood disorders still need further investigation along with intervention studies.en
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Res Grp Mol & Behav Neurosci Bipolar Disorder, Sao Paulo, Brazil
dc.description.affiliationAmity Univ Uttar Pradesh, Amity Inst Biotechnol, Ctr Med Biotechnol, Noida, India
dc.description.affiliationUniv Toronto, UHN, MDPU, Toronto, ON, Canada
dc.description.affiliationPontifical Catholic Univ Rio Grande Sul PUCRS, Inst Biomed Res, Lab Immunosenescence, Porto Alegre, RS, Brazil
dc.description.affiliationPontificia Univ Catolica Rio Grande do Sul, Postgrad Program Psychol, Cognit Neurosci Res Grp GNCD, Porto Alegre, RS, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Pharmacol, Sao Paulo, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Res Grp Mol & Behav Neurosci Bipolar Disorder, Sao Paulo, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Dept Pharmacol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipcoordination of the Improvement of Higher Education Personnel (CAPES), Brazil
dc.description.sponsorshipNational Council of Technological and Scientific Development (CNPq), Brazil
dc.format.extent739-749
dc.identifierhttp://dx.doi.org/10.1515/revneuro-2017-0001
dc.identifier.citationReviews In The Neurosciences. Berlin, v. 28, n. 7, p. 739-749, 2017.
dc.identifier.doi10.1515/revneuro-2017-0001
dc.identifier.issn0334-1763
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57300
dc.identifier.wosWOS:000412280400005
dc.language.isoeng
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofReviews In The Neurosciences
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectbipolar disorderen
dc.subjectmajor depression disorderen
dc.subjectmicrobiomeen
dc.subjectmicrobiotaen
dc.subjectmood disordersen
dc.subjectprobioticsen
dc.titleMicrobiota abnormalities and the therapeutic potential of probiotics in the treatment of mood disordersen
dc.typeinfo:eu-repo/semantics/article
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