Intrauterine exposure to diesel exhaust diminishes adult ovarian reserve

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dc.contributor.authorOgliari, Karolyn Sassi
dc.contributor.authorLichtenfels, Ana Julia de Faria Coimbra
dc.contributor.authorMarchi, Mary Rosa Rodrigues de
dc.contributor.authorFerreira, Alice Teixeira [UNIFESP]
dc.contributor.authorDolhnikoff, Marisa
dc.contributor.authorSaldiva, Paulo Hilario Nascimento
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Estate São Paulo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:31:36Z
dc.date.available2016-01-24T14:31:36Z
dc.date.issued2013-05-01
dc.description.abstractObjective: To analyze ovarian and uterine morphologic changes resulting from intrauterine and postnatal exposure to diesel exhaust.Design: Crossover study. Experimental groups: intrauterine and postnatal clean air exposure; intrauterine exposure to diesel only; postnatal exposure to diesel only; and intrauterine and postnatal exposure to diesel.Setting: Laboratory of Experimental Air Pollution.Animal(s): Swiss mice.Intervention(s): Mice exposed to diesel exhaust with doses that correspond to the daily average PM2.5 levels (fine particles in the ambient air 2.5 mu m or less in size) reported by the World Health Organization.Main Outcome Measure(s): Morphometric analyses of the ovaries and uterus were performed to define the relative area occupied by follicles, corpus luteum, and stroma and the proportionate area of glands, epithelial layer, and stroma within the uterine endometrium. Result(s): A significant reduction in the proportion of primordial follicles was observed in intrauterine-exposed animals, those exposed during the postnatal period, and in animals exposed during both phases. Primary follicle proportion was reduced in animals exposed during pregnancy. No significant changes were detected in uterine morphology.Conclusion(s): Intrauterine exposure to acceptable levels of diesel exhaust compromises the reproductive potential of female mice, diminishing ovarian reserve when sexual maturity is achieved. This effect could increase the risk of premature menopause. the findings raise concern about current environmental guidelines for diesel exposure, warranting more careful examination of this issue in humans by regulatory authorities. ((c) 2013 by American Society for Reproductive Medicine.)en
dc.description.affiliationUniv São Paulo, Sch Med, Dept Pathol, Lab Expt Air Pollut, BR-05508 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Lab Expt Therapeut, BR-05508 São Paulo, Brazil
dc.description.affiliationUniv Estate São Paulo, Inst Chem, Dept Analyt Chem, Araraquara, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Biophys & Mol Biol, Porto Alegre, RS, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Biophys & Mol Biol, Porto Alegre, RS, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipLaboratorio de Investigacao Medica do Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo
dc.description.sponsorshipIDLaboratorio de Investigacao Medica do Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo: LIM05
dc.format.extent1681-+
dc.identifierhttp://dx.doi.org/10.1016/j.fertnstert.2013.01.103
dc.identifier.citationFertility and Sterility. New York: Elsevier B.V., v. 99, n. 6, p. 1681-+, 2013.
dc.identifier.doi10.1016/j.fertnstert.2013.01.103
dc.identifier.issn0015-0282
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36225
dc.identifier.wosWOS:000318612400035
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofFertility and Sterility
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectOvarian follicleen
dc.subjectmenopauseen
dc.subjectvehicle emissionsen
dc.subjectmiceen
dc.titleIntrauterine exposure to diesel exhaust diminishes adult ovarian reserveen
dc.typeinfo:eu-repo/semantics/article
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