Progression of changes in the sensorial elements of the cochlear and peripheral vestibular systems: The otitis media continuum

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dc.contributor.authorMonsanto, Rafael da Costa [UNIFESP]
dc.contributor.authorSchachern, Patricia
dc.contributor.authorPaparella, Michael M.
dc.contributor.authorCureoglu, Sebahattin
dc.contributor.authorPenido, Norma de Oliveira [UNIFESP]
dc.date.accessioned2019-08-19T11:50:18Z
dc.date.available2019-08-19T11:50:18Z
dc.date.issued2017
dc.description.abstractOur study aimed to evaluate pathologic changes in the cochlear (inner and outer hair cells and stria vascularis) and vestibular (vestibular hair cells, dark, and transitional cells) sensorial elements in temporal bones from donors who had otitis media. We studied 40 temporal bones from such donors, which were categorized in serous otitis media (SOM), serous-purulent otitis media (SPOM), mucoid/mucoid-purulent otitis media (MOM/MPOM), and chronic otitis media (COM)en
dc.description.abstractcontrol group comprised 10 nondiseased temporal bones. We found significant loss of inner and outer cochlear hair cells in the basal turn of the SPOM, MOM/MPOM and COM groupsen
dc.description.abstractsignificant loss of vestibular hair cells was observed in the MOM/MPOM and COM groups. All otitis media groups had smaller mean area of the stria vascularis in the basal turn of the cochlea when compared to controls. In conclusion, our study demonstrated more severe pathologic changes in the later stages of the continuum of otitis media (MOM/MPOM and COM). Those changes seem to progress from the basal turn of the cochlea (stria vascularis, then inner and outer hair cells) to the middle turn of the cochlea and to the saccule and utricle in the MOM/MPOM and COM stages. (C) 2017 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Minnesota, Dept Otolaryngol, Otopathol Lab, 2001 6th St SE,Lions Res Bldg,Room 210, Minneapolis, MN 55455 USA
dc.description.affiliationUniv Fed São Paulo UNIFESP, Dept Otorhinolaryngol Head & Neck Surg, Escola Paulista Med, Rua Otonis 700, BR-04025002 São Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed São Paulo UNIFESP, Dept Otorhinolaryngol Head & Neck Surg, Escola Paulista Med, Rua Otonis 700, BR-04025002 São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Institute on Deafness and Other Communication Disorders of the US National Institutes of Health
dc.description.sponsorshipInternational Hearing Foundation
dc.description.sponsorshipStarkey Hearing Foundation
dc.description.sponsorshipLions 5M Hearing Foundation
dc.description.sponsorshipIDNational Institute on Deafness and Other Communication Disorders of the US National Institutes of Health: U24 DC011968
dc.format.extent2-10
dc.identifierhttp://dx.doi.org/10.1016/j.heares.2017.05.003
dc.identifier.citationHearing Research. Amsterdam, v. 351, p. 2-10, 2017.
dc.identifier.doi10.1016/j.heares.2017.05.003
dc.identifier.issn0378-5955
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/51508
dc.identifier.wosWOS:000405155500001
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectOtitis mediaen
dc.subjectCochlear pathologyen
dc.subjectVestibular pathologyen
dc.subjectStria vascularisen
dc.subjectCochlear hair cellsen
dc.subjectVestibular hair cellsen
dc.titleProgression of changes in the sensorial elements of the cochlear and peripheral vestibular systems: The otitis media continuumen
dc.typeinfo:eu-repo/semantics/article
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