A polymorphism in the promoter of UCP2 gene modulates lipid levels in patients with type 2 diabetes

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dc.contributor.authorReis, A. F.
dc.contributor.authorDubois-Laforgue, D.
dc.contributor.authorBellanne-Chantelot, C.
dc.contributor.authorTimsit, J.
dc.contributor.authorVelho, G.
dc.contributor.institutionHop St Vincent de Paul
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHop Cochin
dc.contributor.institutionHop St Antoine
dc.date.accessioned2016-01-24T12:37:17Z
dc.date.available2016-01-24T12:37:17Z
dc.date.issued2004-08-01
dc.description.abstractA G/A single nucleotide polymorphism (SNP) in the position -866 of the UCP2 promoter modulates UCP2 expression in adipose tissue and pancreatic beta-cell, and is associated with variations of body mass index (BMI) and insulin secretion in nondiabetic subjects. We investigated associations of this SNP with traits related to obesity, dyslipidemia, and hyperglycemia in patients with type 2 diabetes. the -866 G/A SNP in the UCP2 promoter was genotyped by PCR/RFLP in 681 type 2 diabetic patients. Increased triglyceride (greater than or equal to1.70mM), total cholesterol (greater than or equal to6.0mM) and LDL-cholesterol (greater than or equal to3.35mM) levels were significantly less frequent in homozygous carriers of the G-allele than in homozygous carriers of the A-allele. Odds ratios for the risk of dyslipidemia in GG vs AA carriers were 0.45, 0.57, and 0.50, for triglyceride, total cholesterol and LDL-cholesterol, respectively (all p < 0.007). No genetic effects of this polymorphism on the BMI or on traits related to the severity of hyperglycemia were observed. in conclusion, a common polymorphism in the promoter region of the UCP2 gene modulates triglycerides and cholesterol levels in French Caucasian subjects with type 2 diabetes. the implications of this effect in the evolution of type 2 diabetes and its macrovascular complications deserve to be investigated. (C) 2004 Elsevier Inc. All rights reserved.en
dc.description.affiliationHop St Vincent de Paul, INSERM, Unit 561, F-75674 Paris, France
dc.description.affiliationUniversidade Federal de São Paulo, Mol Endocrinol Lab, São Paulo, Brazil
dc.description.affiliationHop Cochin, Immuno Diabetol Dept, F-75674 Paris, France
dc.description.affiliationHop St Antoine, Mol Biol Unit, F-75571 Paris, France
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Mol Endocrinol Lab, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent339-344
dc.identifierhttp://dx.doi.org/10.1016/j.ymgme.2004.06.008
dc.identifier.citationMolecular Genetics and Metabolism. San Diego: Academic Press Inc Elsevier Science, v. 82, n. 4, p. 339-344, 2004.
dc.identifier.doi10.1016/j.ymgme.2004.06.008
dc.identifier.issn1096-7192
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/27860
dc.identifier.wosWOS:000223570900010
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofMolecular Genetics and Metabolism
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectUCP2en
dc.subjecttype 2 diabetes mellitusen
dc.subjectdyslipidemiaen
dc.subjectsingle nucleotide polymorphismen
dc.subjectassociation studiesen
dc.titleA polymorphism in the promoter of UCP2 gene modulates lipid levels in patients with type 2 diabetesen
dc.typeinfo:eu-repo/semantics/article
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