Early and late postoperative inflammatory and collagen deposition responses in three different meshes: an experimental study in rats

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dc.contributor.authorPereira-lucena, C. G. [UNIFESP]
dc.contributor.authorArtigiani Neto, R. [UNIFESP]
dc.contributor.authorRezende, D. T. de [UNIFESP]
dc.contributor.authorLopes-Filho, G. de J. [UNIFESP]
dc.contributor.authorMatos, D. [UNIFESP]
dc.contributor.authorLinhares, M. M. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:37:38Z
dc.date.available2016-01-24T14:37:38Z
dc.date.issued2014-08-01
dc.description.abstractAlthough meshes reduce abdominal hernia recurrence, they increase the risk of inflammatory complications. This study aimed to compare the early and late postoperative inflammation and collagen deposition responses induced by three meshes.Rats were allocated into three groups. in group I, a polypropylene (PP) mesh was implanted in the abdominal wall. in groups II and III, PP + polyglactin (PP + PG) and PP + titanium (PP + TI) meshes were employed, respectively. On the seventh (7th) postoperative day, collagen deposition and inflammation were evaluated, and immunohistochemistry was performed on abdominal wall biopsies. These data were compared with those obtained on the fortieth (40th) postoperative day in a previous study.The early inflammatory responses were the same in all groups. With time, it decreased in group I (p = 0.047) and increased in group II (p = 0.003). Group I exhibited early elevated VEGF (p < 0.001), COX2 (p < 0.001), and collagen (p = 0.023) levels, and group II exhibited the most severe inflammatory tissue response. On the 40th postoperative day, the VEGF (p < 0.001) and collagen (p < 0.005) were reduced as compared with the 7th postoperative day in all groups.Belatedly, the inflammatory reaction decreased in PP mesh group and increased in PP + PG mesh group. the PP mesh induced early great elevations in VEGF, COX2 and collagen levels, whereas the PP + PG mesh caused severe tissue inflammation with small elevation in these levels. PP + TI mesh induced inflammatory response levels between the others. in conclusion, the inflammatory response depends on the mesh density and also the mesh material with clinical implications.en
dc.description.affiliationUniversidade Federal de São Paulo, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent563-570
dc.identifierhttp://dx.doi.org/10.1007/s10029-013-1206-4
dc.identifier.citationHernia. New York: Springer, v. 18, n. 4, p. 563-570, 2014.
dc.identifier.doi10.1007/s10029-013-1206-4
dc.identifier.issn1265-4906
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38030
dc.identifier.wosWOS:000339876400017
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofHernia
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectHerniaen
dc.subjectMeshen
dc.subjectInflammatory responseen
dc.subjectCollagenen
dc.subjectVEGFen
dc.subjectCOX2.INFLAMMATORYen
dc.titleEarly and late postoperative inflammatory and collagen deposition responses in three different meshes: an experimental study in ratsen
dc.typeinfo:eu-repo/semantics/article
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