THC inhibits the expression of ethanol-induced locomotor sensitization in mice

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dc.citation.volume65
dc.contributor.authorFilev, Renato [UNIFESP]
dc.contributor.authorEngelke, Douglas S.
dc.contributor.authorDa Silveira, Dartiu X. [UNIFESP]
dc.contributor.authorMello, Luiz E. [UNIFESP]
dc.contributor.authorSantos-Junior, Jair G.
dc.coverageNew York
dc.date.accessioned2020-09-01T13:21:12Z
dc.date.available2020-09-01T13:21:12Z
dc.date.issued2017
dc.description.abstractThe motivational circuit activated by ethanol leads to behavioral changes that recruit the endocannabinoid system (ECS). Case reports and observational studies suggest that the use of Cannabis sp. mitigates problematic ethanol consumption in humans. Here, we verified the effects of the two main phytocannabinoid compounds of Cannabis sp., cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC), in the expression of ethanol-induced locomotor sensitization in mice. Male adult DBA/2 mice were exposed to locomotor sensitization by daily intraperitoneal injections of ethanol (2.5 g/kg) for 12 days; control groups received saline. After the acquisition phase, animals were treated with cannabinoids: CBD (2.5 mg/kg); THC (2.5 mg/kg); CBD + THC (1:1 ratio), or vehicle for 4 days with no access to ethanol during this period. One day after the last cannabinoid injection, all animals were challenged with ethanol (2.0 g/kg) to evaluate the expression of the locomotor sensitization. Mice treated with THC alone or THC + CBD showed reduced expression of locomotor sensitization, compared to the vehicle control group. No effects were observed with CBD treatment alone. Our findings showing that phytocannabinoid treatment prevents the expression of behavioral sensitization in mice provide insight into the potential therapeutic use of phytocannabinoids in alcohol-related problems. (C) 2017 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Physiol, Neurobiol Lab, R Pedro de Toledo,669 3rd Floor, BR-04039032 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychiat & Med Psychol, R Borges Lagoa,570 Vila Clementino, BR-04038000 Sao Paulo, SP, Brazil
dc.description.affiliationFac Ciencias Med Santa Casa Sao Paulo, Dept Physiol Sci, Rua Dr Cesario Motta Jr 61, BR-01221020 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Neurobiol & Anat, 6431 Fannin St,Room 7-512, Houston, TX 77030 USA
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Physiol, Neurobiol Lab, R Pedro de Toledo,669 3rd Floor, BR-04039032 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychiat & Med Psychol, R Borges Lagoa,570 Vila Clementino, BR-04038000 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo
dc.description.sponsorshipIDFAPESP: 2009/16307-2
dc.format.extent31-35
dc.identifierhttp://dx.doi.org/10.1016/j.alcohol.2017.06.004
dc.identifier.citationAlcohol. New York, v. 65, p. 31-35, 2017.
dc.identifier.doi10.1016/j.alcohol.2017.06.004
dc.identifier.issn0741-8329
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58120
dc.identifier.wosWOS:000415910000005
dc.language.isoeng
dc.publisherElsevier Science Inc
dc.relation.ispartofAlcohol
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAlcoholen
dc.subjectCannabisen
dc.subjectSensitizationen
dc.subjectDependenceen
dc.subjectEndocannabinoid systemen
dc.subjectBehavioren
dc.titleTHC inhibits the expression of ethanol-induced locomotor sensitization in miceen
dc.typeinfo:eu-repo/semantics/article
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