Low-level laser therapy inhibits bronchoconstriction, Th2 inflammation and airway remodeling in allergic asthma

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dc.contributor.authorSilva, Vanessa Ribeiro da
dc.contributor.authorMarcondes, Priscila Toledo [UNIFESP]
dc.contributor.authorSilva, M.
dc.contributor.authorVillaverde, Antonio Balbin
dc.contributor.authorCastro-Faria-Neto, Hugo Caire
dc.contributor.authorVieira, Rodolfo de Paula [UNIFESP]
dc.contributor.authorAimbire, Flavio [UNIFESP]
dc.contributor.authorOliveira, Ana Paula L. de
dc.contributor.institutionNove de Julho Univ UNINOVE
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUnicastelo
dc.contributor.institutionFiocruz MS
dc.date.accessioned2016-01-24T14:35:33Z
dc.date.available2016-01-24T14:35:33Z
dc.date.issued2014-04-01
dc.description.abstractLow-level laser therapy (LLLT) controls bronchial hyperresponsiveness (BHR) associated with increased RhoA expression as well as pro-inflammatory mediators associated with NF-kB in acute lung inflammation. Herein, we explore if LLLT can reduce both BHR and Th2 cytokines in allergic asthma. Mice were studied for bronchial reactivity and lung inflammation after antigen challenge. BHR was measured through dose-response curves to acetylcholine. Some animals were pretreated with a RhoA inhibitor before the antigen. LLLT (660 nm, 30 mW and 5.4 J) was applied on the skin over the right upper bronchus and two irradiation protocols were used. Reduction of BHR post LLLT coincided with lower RhoA expression in bronchial muscle as well as reduction in eosinophils and eotaxin. LLLT also diminished ICAM expression and Th2 cytokines as well as signal transducer and activator of transduction 6 (STAT6) levels in lungs from challenged mice. Our results demonstrated that LLLT reduced BHR via RhoA and lessened allergic lung inflammation via STAT6. (C) 2014 Elsevier B.V. All rights reserved.en
dc.description.affiliationNove de Julho Univ UNINOVE, Lab Pulm & Exercise Immunol LABPEI, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Sci & Technol, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnicastelo, Inst Biomed Engn, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationFiocruz MS, IOC, Lab Immunopharmacol, Rio de Janeiro, RJ, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Sci & Technol, Sao Jose Dos Campos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.description.sponsorshipIDFAPESP: 2008/08838-5pt
dc.format.extent37-48
dc.identifierhttps://dx.doi.org/10.1016/j.resp.2014.01.008
dc.identifier.citationRespiratory Physiology & Neurobiology. Amsterdam: Elsevier B.V., v. 194, p. 37-48, 2014.
dc.identifier.doi10.1016/j.resp.2014.01.008
dc.identifier.issn1569-9048
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/37626
dc.identifier.wosWOS:000334002400007
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofRespiratory Physiology & Neurobiology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectAllergyen
dc.subjectAirway hyperresponsivenessen
dc.subjectRhoAen
dc.subjectEosinophilsen
dc.subjectSTAT6en
dc.subjectLaser therapyen
dc.titleLow-level laser therapy inhibits bronchoconstriction, Th2 inflammation and airway remodeling in allergic asthmaen
dc.typeinfo:eu-repo/semantics/article
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