Gallic Acid-Loaded Gel Formulation Combats Skin Oxidative Stress: Development, Characterization and Ex Vivo Biological Assays

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dc.contributor.authorMonteiro e Silva, Silas Arandas [UNIFESP]
dc.contributor.authorFioramonti Calixto, Giovana Maria
dc.contributor.authorCajado, Juliana
dc.contributor.authorAntunes de Carvalho, Patricia Caballieri [UNIFESP]
dc.contributor.authorRodero, Camila Fernanda
dc.contributor.authorChorilli, Marlus
dc.contributor.authorLeonardi, Gislaine Ricci [UNIFESP]
dc.date.accessioned2019-08-19T11:48:36Z
dc.date.available2019-08-19T11:48:36Z
dc.date.issued2017
dc.description.abstractOxidative stress, which is a result of overproduction and accumulation of free radicals, is the main cause of several skin degenerative diseases, such as aging. Polyphenols, such as gallic acid, are an important class of naturally occurring antioxidants. They have emerged as strong antioxidants that can be used as active cosmetics. The purpose of this study was to develop a gallic acid-loaded cosmetic gel formulation and characterize it using rheological, mechanical, and bioadhesive tests. Its antioxidant effect in the stratumcorneumwas evaluated by a non-invasivemethod. According to the characterization tests, the formulation exhibited skin adhesiveness and pseudoplastic behavior without thixotropy, rendering it suitable for use as a cosmetic formulation. Furthermore, the non-invasive method indicated the antioxidant effect in the stratum corneum, with the global lipid peroxide reduction being 33.97 +/- 11.66%. Thus, we were able to develop a promising gallic acid-loaded gel formulation that could reduce lipid peroxides and thus combat skin oxidative stress.en
dc.description.affiliationFed Univ São Paulo UNIFESP, Dept Med, BR-04023062 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14800903 Araraquara, Brazil
dc.description.affiliationUniv São Paulo, Dept Food Sci, BR-05508000 São Paulo, Brazil
dc.description.affiliationFed Univ São Paulo UNIFESP, Inst Environm Chem & Pharmaceut Sci, BR-09913030 Diadema, Brazil
dc.description.affiliationUniv Campinas UNICAMP, Fac Pharmaceut Sci, BR-13083871 Campinas, SP, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Dept Med, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Inst Environm Chem & Pharmaceut Sci, BR-09913030 Diadema, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipPrograma de Apoio ao Desenvolvimento Científico-Faculdade de Ciências Farmacêuticas-UNESP (PADC-FCF)
dc.description.sponsorshipIDFAPESP: 2011/04908-1
dc.description.sponsorshipIDFAPESP: 2013/01565-1
dc.description.sponsorshipIDFAPESP: 2013/01118-5
dc.description.sponsorshipIDFAPESP: 2014/24180-0
dc.description.sponsorshipIDFAPESP: 2017/17597-0
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3390/polym9090391
dc.identifier.citationPolymers. Basel, v. 9, n. 9, p. -, 2017.
dc.identifier.doi10.3390/polym9090391
dc.identifier.fileWOS000411524400010.pdf
dc.identifier.issn2073-4360
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/51294
dc.identifier.wosWOS:000411524400010
dc.language.isoeng
dc.publisherMdpi Ag
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectantioxidantsen
dc.subjectgallic aciden
dc.subjectpolymersen
dc.subjectskin administrationen
dc.titleGallic Acid-Loaded Gel Formulation Combats Skin Oxidative Stress: Development, Characterization and Ex Vivo Biological Assaysen
dc.typeinfo:eu-repo/semantics/article
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