Effects of melatonin on the endometrial morphology and embryo implantation in rats

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dc.contributor.authorDair, Elisabete Lilian [UNIFESP]
dc.contributor.authorSimoes, Ricardo Santos [UNIFESP]
dc.contributor.authorSimoes, Manuel Jesus [UNIFESP]
dc.contributor.authorRomeu, Lucrecia Regina Gomes [UNIFESP]
dc.contributor.authorOliveira-Filho, Ricardo Martins
dc.contributor.authorHaidar, Mauro Abi [UNIFESP]
dc.contributor.authorBaracat, Edmund Chada [UNIFESP]
dc.contributor.authorSoares, Jose Maria [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T13:49:45Z
dc.date.available2016-01-24T13:49:45Z
dc.date.issued2008-05-01
dc.description.abstractObjective: To determine the effects of melatonin on rat endometrium morphology and embryo implantation.Design: Experimental study.Setting: Federal University of São Paulo, Brazil.Animal(s): Forty female rats.Intervention(s): GI: control, GII: sham-operated, GIII: pinealectomized, and GIV: pinealectomized rats that received melatonin during 3 months. the GI, GII, and Gin groups received the vehicle of melatonin (NaCl + ethanol). At the end of the treatment, the animals were killed during the estrous phase; the uterus was removed for morphometric analysis. Urine was collected for 6-sulfatoxymelatonin. Blood was collected for estrogen (E) and progesterone (P) level determinations. in a second experiment, female rats were used to evaluate the endometrial embryo implantation.Main Outcome Measure(s): Endometrial morphology and embryo implantation.Result(s): Gin presented the highest values for endometrial area and thickness index, number of endometrial glands, and eosinophils. the number of vessels of groups I, II, and IV was fewer than that of Gin. the highest number of eosinophils was detected in Gin in comparison to other groups. the implantation rate in Gin was the lowest of all groups. This implantation rate was significantly increased and restored toward normal in GIV.Conclusion(s): Our data suggested that, in nonphotoperiodic animals such as rats, melatonin may positively affect the endometrial morphology and improve embryo implantation.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Gynecol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Morphol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Pharmacol, Inst Biomed Sci, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Dept Obstet & Gynecol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Gynecol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Morphol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1299-1305
dc.identifierhttp://dx.doi.org/10.1016/j.fertnstert.2007.03.050
dc.identifier.citationFertility and Sterility. New York: Elsevier B.V., v. 89, p. 1299-1305, 2008.
dc.identifier.doi10.1016/j.fertnstert.2007.03.050
dc.identifier.issn0015-0282
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30604
dc.identifier.wosWOS:000256075500002
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofFertility and Sterility
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectmelatoninen
dc.subjectendometriumen
dc.subjectpineal glanden
dc.subjectembryo implantationen
dc.titleEffects of melatonin on the endometrial morphology and embryo implantation in ratsen
dc.typeinfo:eu-repo/semantics/article
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