Sodium nitrite downregulates vascular NADPH oxidase and exerts antihypertensive effects in hypertension
dc.contributor.author | Montenegro, Marcelo Freitas | |
dc.contributor.author | Amaral, Jefferson Henrich | |
dc.contributor.author | Pinheiro, Lucas Cézar | |
dc.contributor.author | Sakamoto, Eliana Kiyomi | |
dc.contributor.author | Ferreira, Graziele C. | |
dc.contributor.author | Reis, Rosana Inacio dos [UNIFESP] | |
dc.contributor.author | Marcal, Diogo Machado de Oliveira | |
dc.contributor.author | Pereira, Romaiana Picada | |
dc.contributor.author | Tanus-Santos, Jose Eduardo | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.contributor.institution | Universidade Estadual de Campinas (UNICAMP) | |
dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
dc.contributor.institution | Universidade Federal de Sergipe (UFS) | |
dc.date.accessioned | 2016-01-24T14:16:54Z | |
dc.date.available | 2016-01-24T14:16:54Z | |
dc.date.issued | 2011-07-01 | |
dc.description.abstract | Dietary nitrite and nitrate are important sources of nitric oxide (NO). However, the use of nitrite as an antihypertensive drug may be limited by increased oxidative stress associated with hypertension. We evaluated the antihypertensive effects of sodium nitrite given in drinking water for 4 weeks in two-kidney one-clip (21(1 C) hypertensive rats and the effects induced by nitrite on NO bioavailability and oxidative stress. We found that, even under the increased oxidative stress conditions present in 2K1C hypertension, nitrite reduced systolic blood pressure in a dose-dependent manner. Whereas treatment with nitrite did not significantly change plasma nitrite concentrations in 2K1C rats, it increased plasma nitrate levels significantly. Surprisingly, nitrite treatment exerted antioxidant effects in both hypertensive and sham-normotensive control rats. A series of in vitro experiments was carried out to show that the antioxidant effects induced by nitrite do not involve direct antioxidant effects or xanthine oxidase activity inhibition. Conversely, nitrite decreased vascular NADPH oxidase activity. Taken together, our results show for the first time that nitrite has antihypertensive effects in 2K1C hypertensive rats, which may be due to its antioxidant properties resulting from vascular NADPH oxidase activity inhibition. (C) 2011 Elsevier Inc. All rights reserved. | en |
dc.description.affiliation | Univ São Paulo, Fac Med Ribeirao Preto, Dept Pharmacol, BR-14049900 Ribeirao Preto, SP, Brazil | |
dc.description.affiliation | Univ Estadual Campinas, Fac Med Sci, Dept Pharmacol, BR-13081970 Campinas, SP, Brazil | |
dc.description.affiliation | Universidade Federal de São Paulo, Dept Med, Div Nephrol, BR-04023040 São Paulo, Brazil | |
dc.description.affiliation | Univ Fed Santa Maria, Dept Chem, BR-97105900 Santa Maria, RS, Brazil | |
dc.description.affiliationUnifesp | Universidade Federal de São Paulo, Dept Med, Div Nephrol, BR-04023040 São Paulo, Brazil | |
dc.description.source | Web of Science | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description.sponsorship | Programa Nacional de Cooperacao Academica | |
dc.format.extent | 144-152 | |
dc.identifier | http://dx.doi.org/10.1016/j.freeradbiomed.2011.04.005 | |
dc.identifier.citation | Free Radical Biology and Medicine. New York: Elsevier B.V., v. 51, n. 1, p. 144-152, 2011. | |
dc.identifier.doi | 10.1016/j.freeradbiomed.2011.04.005 | |
dc.identifier.file | WOS000291628700014.pdf | |
dc.identifier.issn | 0891-5849 | |
dc.identifier.uri | http://repositorio.unifesp.br/handle/11600/33813 | |
dc.identifier.wos | WOS:000291628700014 | |
dc.language.iso | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation.ispartof | Free Radical Biology and Medicine | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dc.subject | Nitrite | en |
dc.subject | Antioxidants | en |
dc.subject | NADPH oxidase | en |
dc.subject | Nitric oxide | en |
dc.subject | Xanthine oxidase | en |
dc.subject | 2K1C hypertension | en |
dc.subject | Free radicals | en |
dc.title | Sodium nitrite downregulates vascular NADPH oxidase and exerts antihypertensive effects in hypertension | en |
dc.type | info:eu-repo/semantics/article |
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