The intensive care medicine research agenda on septic shock

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dc.contributor.authorPerner, Anders
dc.contributor.authorGordon, Anthony C.
dc.contributor.authorAngus, Derek C.
dc.contributor.authorLamontagne, Francois
dc.contributor.authorMachado, Flavia [UNIFESP]
dc.contributor.authorRussell, James A.
dc.contributor.authorTimsit, Jean-Francois
dc.contributor.authorMarshall, John C.
dc.contributor.authorMyburgh, John
dc.contributor.authorShankar-Hari, Manu
dc.contributor.authorSinger, Mervyn
dc.date.accessioned2019-08-19T11:49:30Z
dc.date.available2019-08-19T11:49:30Z
dc.date.issued2017
dc.description.abstractSeptic shock remains a global health challenge with millions of cases every year, high rates of mortality and morbidity, impaired quality of life among survivors and relatives, and high resource use both in developed and developing nations. Care and outcomes are improving through organisational initiatives and updated clinical practice guidelines based on clinical research mainly carried out by large collaborative networks. This progress is likely to continue through the collaborative work of the established and merging trials groups in many parts of the world and through refined trial methodology and translational work. In this review, international experts summarize the current position of clinical research in septic shock and propose a research agenda to advance this field.en
dc.description.affiliationUniv Copenhagen, Dept Intens Care, Rigshosp, Copenhagen, Denmark
dc.description.affiliationImperial Coll London, Dept Surg & Canc, Sect Anaesthet Pain Med & Intens Care, London, England
dc.description.affiliationUniv Pittsburgh, Sch Med, Dept Crit Care Med, Pittsburgh, PA USA
dc.description.affiliationUniv Sherbrooke, Fac Med & Sci Sante, Dept Med, Ctr Rech,CHU Sherbrooke, Sherbrooke, PQ, Canada
dc.description.affiliationUniv Fed São Paulo, São Paulo, Brazil
dc.description.affiliationUniv British Columbia, St Pauls Hosp, Ctr Heart Lung Innovat, Vancouver, BC, Canada
dc.description.affiliationUniv Paris Diderot, ICU,Bichat Univ Hosp, APHP,Med & Infect Dis, Inserm,UMR 1137,IAME, Paris, France
dc.description.affiliationUniv Toronto, St Michaels Hosp, Dept Surg & Crit Care Med, Keenan Res Ctr Biomed Sci, Toronto, ON, Canada
dc.description.affiliationUniv New South Wales, St George Clin Sch, George Inst Global Hlth, Sydney, NSW, Australia
dc.description.affiliationKings Coll London, Dept Immunobiol, Guys & St Thomas Hosp NHS Fdn Trust, London, England
dc.description.affiliationUCL, Bloomsbury Inst Intens Care Med, Div Med, London, England
dc.description.affiliationUnifespUniv Fed São Paulo, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFerring Pharmaceuticals
dc.description.sponsorshipFresenius Kabi
dc.description.sponsorshipCSL Behring
dc.description.sponsorshipOrion Pharmaceuticals
dc.description.sponsorshipAmomed
dc.description.sponsorshipTenax Therapeutics
dc.description.sponsorshipHCA International
dc.description.sponsorshipNIHR
dc.description.sponsorshipNIHR Research Professorship award
dc.description.sponsorshipAbbott
dc.description.sponsorshipBayer
dc.description.sponsorshipBeckman-Coulter
dc.description.sponsorshipBiocartis
dc.description.sponsorshipGenMark
dc.description.sponsorshipGlaxoSmithKline
dc.description.sponsorshipSobi
dc.description.sponsorshipFerring
dc.description.sponsorshipBaxter Healthcare
dc.description.sponsorshipPractitioner Fellowship from the National Health and Medical Research Council of Australia
dc.description.sponsorshipGrifols
dc.description.sponsorshipLa Jolla Pharmaceuticals
dc.description.sponsorshipCytoVale Inc.
dc.description.sponsorshipAsahi Kesai Pharmaceuticals of America (AKPA)
dc.description.sponsorshipNational Institute for Health Research Clinician Scientist Award
dc.description.sponsorshipUK Department of Health
dc.description.sponsorshipIDNational Institute for Health Research Clinician Scientist Award: CS-2016-16-011
dc.format.extent1294-1305
dc.identifierhttp://dx.doi.org/10.1007/s00134-017-4821-1
dc.identifier.citationIntensive Care Medicine. New York, v. 43, n. 9, p. 1294-1305, 2017.
dc.identifier.doi10.1007/s00134-017-4821-1
dc.identifier.issn0342-4642
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/51344
dc.identifier.wosWOS:000408116700010
dc.language.isoeng
dc.publisherSpringer
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectClinical researchen
dc.subjectCritical careen
dc.subjectIntensive careen
dc.subjectICUen
dc.subjectRandomized trialsen
dc.subjectSepsisen
dc.subjectSeptic shocken
dc.titleThe intensive care medicine research agenda on septic shocken
dc.typeinfo:eu-repo/semantics/article
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