Cutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticide

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dc.contributor.authorFernandes, Tania Rita Moreno de Oliveira [UNIFESP]
dc.contributor.authorSantos, Itamar [UNIFESP]
dc.contributor.authorKorinsfky, Juliana Pedrosa
dc.contributor.authorSilva, Benedyto Savio de Lima e [UNIFESP]
dc.contributor.authorCarvalho, Luis Otavio
dc.contributor.authorPlapler, Helio [UNIFESP]
dc.contributor.institutionFed Univ Sao Francisco Valley UNIVASF
dc.contributor.institutionFundacao Univ Fed Vale Sao Francisco
dc.contributor.institutionOswaldo Cruz Inst Fdn FioCruz
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T12:39:51Z
dc.date.available2018-06-15T12:39:51Z
dc.date.issued2014-01-01
dc.description.abstractPURPOSE: To study the possible potentiation of the carcinogenic effects of ultraviolet radiation associated with an organophosphate pesticide.METHODS: Forty Wistar rats were assigned into four groups (n=10 each) randomized according to the procedures: group A received only UVR-B radiation; group B, UVR-B for eight weeks followed by a seven week period of pesticide exposure; group C, UVR-B + pesticide concomitantly: group D, only pesticide application. At the end of the fifth, tenth and fifteenth weeks the animals were photographed. Skin biopsy and histopathological study with Hematoxylin-Eosin were done on the fifteenth week. Statistical analysis with Fisher's and Sign (unilateral) tests, 5% value for significance.RESULTS: Macroscopic lesions in the group A evolved from the erythema to erythema + desquamation. The groups B and C, with the association of two carcinogens, and group D presented evolution to keratosis, with higher incidence in group D. The histology showed a significant increase in the severity of injuries when the UVR-B and the pesticide were applied simultaneously, leading to cellular atypia.CONCLUSIONS: Concurrent association of UVR-B to organophosphate pesticide produced more severe lesions microscopically, although this has not been so apparent macroscopically. In daily practice the clinical evaluation should be complemented with laboratory evaluation.en
dc.description.affiliationFed Univ Sao Francisco Valley UNIVASF, Dept Med, Petrolina, PE, Brazil
dc.description.affiliationFundacao Univ Fed Vale Sao Francisco, Dept Nursing, Petrolina, PE, Brazil
dc.description.affiliationOswaldo Cruz Inst Fdn FioCruz, Histol Div, Rio De Janeiro, RJ, Brazil
dc.description.affiliationSao Paulo Fed Univ UNIFESP, Paulista Med Sch EPM, Dept Surg, Sao Paulo, Brazil
dc.description.affiliationUnifespSao Paulo Fed Univ UNIFESP, Paulista Med Sch EPM, Dept Surg, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent7-15
dc.identifierhttp://dx.doi.org/10.1590/S0102-86502014000100002
dc.identifier.citationActa Cirurgica Brasileira. Sao Paulo: Acta Cirurgica Brasileira, v. 29, n. 1, p. 7-15, 2014.
dc.identifier.doi10.1590/S0102-86502014000100002
dc.identifier.fileS0102-86502014000100002.pdf
dc.identifier.issn0102-8650
dc.identifier.scieloS0102-86502014000100002
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/41986
dc.identifier.wosWOS:000330868700002
dc.language.isoeng
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEpidermisen
dc.subjectSolar Radiationen
dc.subjectSkin Neoplasmsen
dc.subjectOrganophosphatesen
dc.subjectRatsen
dc.titleCutaneous changes in rats induced by chronic skin exposure to ultraviolet radiation and organophosphate pesticideen
dc.typeinfo:eu-repo/semantics/article
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