The effect of experimental Bothrops jararaca envenomation on pregnant mice

dc.contributor.authorSpadacci-Morena, D. D.
dc.contributor.authorTomy, S. C. de
dc.contributor.authorSano-Martins, I. S.
dc.contributor.authorKatz, S. G.
dc.contributor.institutionButantan Inst
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:40:57Z
dc.date.available2016-01-24T12:40:57Z
dc.date.issued2006-02-01
dc.description.abstractThe injury caused by the intramuscular injection of a single dose of Bothrops jararaca venom (0.24 mg/kg body weight) to mice on day 8 of pregnancy and examined on day 9 was investigated. Macroscopic and histological examination showed that the bothropic venom caused an increase in the incidence of fetal resorptions. Histologically, a characteristic involution of mature decidua was noticed in saline-treated mice; however, necrotic trophoblast giant cells and decidual cells were also present in this region of mice treated with B. jararaca venom, mainly close to the embryo. Hemorrhagic areas were also observed at maternal-fetal interface, which contained maternal erythrocytes and polymorphonuclears. Plasma fibrinogen levels were lower in envenomed group (p <= 0.0001), but prothrombin time and activated partial thromboplastin time remained unaltered. Total and differential white blood cell counts were not statistically different between groups. Thus, B. jararaca venom causes injuries not only to the fetus, but also to decidual tissue and blood coagulation of pregnant mice. It is not clear, nonetheless, whether disturbances during the development of pregnancy are due to a direct effect of venom on uterus/fetus or to homeostatic changes in dams, such as clotting disturbances, or to both of them. (c) 2005 Elsevier B.V. All rights reserved.en
dc.description.affiliationButantan Inst, Lab Pathophysiol, BR-05503900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Sch Med, Dept Histol & Struct Biol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Sch Med, Dept Histol & Struct Biol, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent196-207
dc.identifierhttp://dx.doi.org/10.1016/j.toxicon.2005.10.016
dc.identifier.citationToxicon. Oxford: Pergamon-Elsevier B.V., v. 47, n. 2, p. 196-207, 2006.
dc.identifier.doi10.1016/j.toxicon.2005.10.016
dc.identifier.issn0041-0101
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28727
dc.identifier.wosWOS:000235798400009
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofToxicon
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectBothrops jararaca venomen
dc.subjectfibrinogenen
dc.subjectantimesometrial deciduaen
dc.subjectpregnancyen
dc.subjectmiceen
dc.titleThe effect of experimental Bothrops jararaca envenomation on pregnant miceen
dc.typeinfo:eu-repo/semantics/article
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