Metabolic alterations in experimental autoimmune encephalomyelitis in mice: effects of prior physical exercise

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dc.citation.issue2
dc.citation.volume48
dc.contributor.authorBernardes, Danielle
dc.contributor.authorOliveira-Lima, Onesia Cristina
dc.contributor.authorSilva, Thiago Vitarelli da
dc.contributor.authorJuliano, Maria Aparecida [UNIFESP]
dc.contributor.authorSantos, Daniel Moreira dos
dc.contributor.authorCarvalho-Tavares, Juliana
dc.coverageNew York
dc.date.accessioned2020-07-22T13:23:11Z
dc.date.available2020-07-22T13:23:11Z
dc.date.issued2016
dc.description.abstractExperimental autoimmune encephalomyelitis (EAE) induces significant reduction of the body mass concomitant to sickness behavior and anorexia. We investigated whether regular physical exercise prevents metabolic alterations associated with body mass loss occurring during EAE inflammatory peak. Female C57BL/6 mice were assigned to the unexercised and exercised (trained) groups. In four weeks, EAE was induced in half of the animals in each group, and the exercise protocol was maintained until 10 days post-induction (dpi 10) completing 6 weeks of regular exercise (forced swimming). At dpi 14, the relative mass of metabolic tissues, serum levels of triglycerides, cholesterol, and glucose, glycogen contents in the muscle and liver, and muscle levels of cytokines were measured. A significantly decreased clinical score associated with attenuation of the body mass loss in exercised EAE animals, as compared to the non-exercised ones, was observed. The associated metabolic parameters were not modified by this approach, although negative correlations between some parameters and clinical score at dpi 14 were observed. Although the prior program of aerobic exercise is capable of decreasing clinical score and body mass loss, it is not sufficient to modify metabolic outcomes associated with inflammation at the EAE peak.en
dc.description.affiliationUniv Fed Minas Gerais, Inst Ciencias Biol, Dept Fisiol & Biofis, Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biofis, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, Belo Horizonte, MG, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biofis, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil)
dc.description.sponsorshipFundacao do Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG, Minas Gerais, Brazil)
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES, Brazil)
dc.format.extent117-121
dc.identifierhttps://dx.doi.org/10.1007/s11062-016-9577-7
dc.identifier.citationNeurophysiology. New York, v. 48, n. 2, p. 117-121, 2016.
dc.identifier.doi10.1007/s11062-016-9577-7
dc.identifier.issn0090-2977
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56076
dc.identifier.wosWOS:000382870900008
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofNeurophysiology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectExperimental autoimmune encephalomyelitis (EAE)en
dc.subjectPhysical exerciseen
dc.subjectCachexiaen
dc.subjectBody massen
dc.subjectMetabolic shiftsen
dc.titleMetabolic alterations in experimental autoimmune encephalomyelitis in mice: effects of prior physical exerciseen
dc.typeinfo:eu-repo/semantics/article
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