Comparison between procalcitonin and C-reactive protein for early diagnosis of children with sepsis or septic shock

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dc.contributor.authorFioretto, Jose R.
dc.contributor.authorMartin, Joelma G.
dc.contributor.authorKurokawa, Cilmery S.
dc.contributor.authorCarpi, Mario F.
dc.contributor.authorBonatto, Rossano C.
dc.contributor.authorMoraes, Marcos A. de
dc.contributor.authorRicchetti, Sandra M. Q.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:05:15Z
dc.date.available2016-01-24T14:05:15Z
dc.date.issued2010-08-01
dc.description.abstractThe objective of the paper is to examine the behavior of C-reactive protein (CRP) and procalcitonin (PCT) in the first 12 h of admission and verify which performs better to differentiate children with septic conditions.Septic children aged between 28 days and 14 years were divided into sepsis (SG; n = 46) and septic shock (SSG; n = 41) groups. CRP and PCT were measured at admission (T0) and 12 h later (T12 h). PCT results were classed as: 0.5 ng/ml = sepsis unlikely; a parts per thousand yen0.5 to < 2 = sepsis possible; a parts per thousand yen2 to < 10 = systemic inflammation; a parts per thousand yen10 = septic shock.At T0, there was a higher frequency of SSG with PCT > 10 compared to SG [SSG: 30 (73.1%) > SG: 14 (30.4%); P < 0.05]. Similar results were observed at T12 h. Pediatric Risk of Mortality I score was significantly higher for SSG patients with higher PCT than SG patients. CRP levels were not statistically different for groups and time points.PCT was better than CRP for diagnosing sepsis and septic shock, mainly at admission, and is related to disease severity.en
dc.description.affiliationUniv Estadual Paulista, Fac Med Botucatu, Dept Pediat, BR-18618970 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, Dept Pediat, Botucatu Med Sch, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 04/03776-0
dc.format.extent581-586
dc.identifierhttp://dx.doi.org/10.1007/s00011-010-0161-0
dc.identifier.citationInflammation Research. Basel: Springer Basel Ag, v. 59, n. 8, p. 581-586, 2010.
dc.identifier.doi10.1007/s00011-010-0161-0
dc.identifier.issn1023-3830
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32764
dc.identifier.wosWOS:000279833800001
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofInflammation Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectProcalcitoninen
dc.subjectC-reactive proteinen
dc.subjectSeptic shocken
dc.subjectChildrenen
dc.subjectCritical careen
dc.titleComparison between procalcitonin and C-reactive protein for early diagnosis of children with sepsis or septic shocken
dc.typeinfo:eu-repo/semantics/article
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