Priapism is Associated with Sleep Hypoxemia in Sickle Cell Disease

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dc.contributor.authorRoizenblatt, Marina [UNIFESP]
dc.contributor.authorFigueiredo, Maria Stella [UNIFESP]
dc.contributor.authorCancado, Rodolfo Delfini
dc.contributor.authorPollack-Filho, Frederico [UNIFESP]
dc.contributor.authorAlmeida Santos Arruda, Martha Mariana de [UNIFESP]
dc.contributor.authorVicari, Perla [UNIFESP]
dc.contributor.authorSato, Joao Ricardo
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorRoizenblatt, Suely [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.date.accessioned2016-01-24T14:27:51Z
dc.date.available2016-01-24T14:27:51Z
dc.date.issued2012-10-01
dc.description.abstractPurpose: We assessed penile rigidity during sleep and the relationship of sleep abnormalities with priapism in adults with sickle cell disease.Materials and Methods: This was a case-control study of 18 patients with sickle cell disease and a history of priapism during the previous year, and 16 controls with sickle cell disease. Participants underwent overnight polysomnography and RigiScan (R) Plus recording to detect penile rigidity oscillations.Results: the priapism group (cases) showed a higher apnea-hypopnea index and oxyhemoglobin desaturation parameters than controls. A lower positive correlation between the apnea-hypopnea index and oxyhemoglobin desaturation time was observed in cases than in controls (Spearman coefficient rho = 0.49, p = 0.05 vs rho = 0.76, p < 0.01), suggesting that desaturation events occurred independently of apnea. Two controls and 14 cases had a total sleep time that was greater than 10% with oxyhemoglobin saturation less than 90% but without CO2 retention. Penile rigidity events were observed during rapid eye movement sleep and during stage 2 of nonrapid eye movement sleep, particularly in cases. the duration of penile rigidity events concomitant to respiratory events was higher in cases than in controls. Regression analysis revealed that the periodic limb movement and desaturation indexes were associated with priapism after adjusting for rapid eye movement sleep and lung involvement. Finally, oxyhemoglobin saturation less than 90% was associated with priapism after adjusting for lung involvement, hyperhemolysis and the apnea-hypopnea index.Conclusions: Oxyhemoglobin desaturation during sleep was associated with priapism history. It may underlie the distribution pattern of penile rigidity events during sleep in these patients.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, Escola Paulista Med, BR-01228200 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Disciplina Hematol & Hemoterapia, Escola Paulista Med, BR-01228200 São Paulo, Brazil
dc.description.affiliationUniv Fed ABC, Disciplina Hematol & Oncol, Fac Ciencias Med Santa Casa São Paulo, São Paulo, Brazil
dc.description.affiliationUniv Fed ABC, Ctr Matemat Computacao & Cognicao, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, Escola Paulista Med, BR-01228200 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Disciplina Hematol & Hemoterapia, Escola Paulista Med, BR-01228200 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fundo de Incentivo a Psicofarmacologia
dc.description.sponsorshipFundacao de Apoio a Pesquisa de São Paulo
dc.description.sponsorshipIDFundacao de Apoio a Pesquisa de São Paulo: 2009/14202-9
dc.format.extent1245-1251
dc.identifierhttp://dx.doi.org/10.1016/j.juro.2012.06.015
dc.identifier.citationJournal of Urology. New York: Elsevier B.V., v. 188, n. 4, p. 1245-1251, 2012.
dc.identifier.doi10.1016/j.juro.2012.06.015
dc.identifier.issn0022-5347
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35376
dc.identifier.wosWOS:000308745400066
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Urology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectpenisen
dc.subjectanemia, sickle cellen
dc.subjectpriapismen
dc.subjectanoxiaen
dc.subjectsleepen
dc.titlePriapism is Associated with Sleep Hypoxemia in Sickle Cell Diseaseen
dc.typeinfo:eu-repo/semantics/article
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