Personality traits in juvenile myoclonic epilepsy: Evidence of cortical abnormalities from a surface morphometry study

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dc.contributor.authorAraujo Filho, Gerardo Maria de [UNIFESP]
dc.contributor.authorAraujo, Thabata Bueno de [UNIFESP]
dc.contributor.authorSato, Joao Ricardo [UNIFESP]
dc.contributor.authorSilva, Ivaldo da [UNIFESP]
dc.contributor.authorLin, Katia [UNIFESP]
dc.contributor.authorCarrete Junior, Henrique [UNIFESP]
dc.contributor.authorYacubian, Elza Márcia Targas [UNIFESP]
dc.contributor.authorJackowski, Andrea Parolin [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.date.accessioned2016-01-24T14:31:43Z
dc.date.available2016-01-24T14:31:43Z
dc.date.issued2013-05-01
dc.description.abstractCluster B personality disorders (PD), characterized as emotional instability, immaturity, lack of discipline, and rapid mood changes, have been observed among patients with juvenile myoclonic epilepsy (JME) and have been associated with a worse seizure outcome. Proper understanding of the neurobiology of PD associated with JME could contribute to understanding the basis for earlier and more effective interventions. in the present study, volumetric and geometric features of cortical structure were assessed through an automated cortical surface reconstruction method aiming to verify possible structural cortical alterations among patients with JME. Twenty-two patients with JME with cluster B PD, 44 patients with JME without psychiatric disorders, and 23 healthy controls were submitted to a psychiatric evaluation through SCID I and SCID II and to an MRI scan. Significant cortical alterations in mesiofrontal and frontobasal regions, as well as in other limbic and paralimbic regions, were observed mainly in patients with JME with PD. the present study adds evidence to the hypothesis of frontal and limbic involvement in the pathophysiology of cluster B PD in JME, regions linked to mood and affective regulation, as well as to impulsivity and social behavior. Moreover, a multidimensional pattern of frontal, limbic, and paralimbic changes was observed through a method of structural analysis which offers different and simultaneous geometric features, allowing the elaboration of important pathophysiologic insights about cluster B PD in JME. (C) 2013 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Psychiat, Lab Interdisciplinar Neurociencias Clin LiNC, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Neurol & Neurosurg, São Paulo, Brazil
dc.description.affiliationUniv Fed ABC, Ctr Math Computat & Cognit, BR-09210170 Santo Andre, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Gynecol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Diagnost Imaging, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Psychiat, Lab Interdisciplinar Neurociencias Clin LiNC, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Neurol & Neurosurg, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Gynecol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Diagnost Imaging, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent385-392
dc.identifierhttp://dx.doi.org/10.1016/j.yebeh.2013.02.004
dc.identifier.citationEpilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 27, n. 2, p. 385-392, 2013.
dc.identifier.doi10.1016/j.yebeh.2013.02.004
dc.identifier.issn1525-5050
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36305
dc.identifier.wosWOS:000317723900021
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEpilepsy & Behavior
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectMagnetic resonance imagingen
dc.subjectCortical surface analysisen
dc.subjectCortical morphologyen
dc.subjectJuvenile myoclonic epilepsyen
dc.subjectCluster B personality disordersen
dc.titlePersonality traits in juvenile myoclonic epilepsy: Evidence of cortical abnormalities from a surface morphometry studyen
dc.typeinfo:eu-repo/semantics/article
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