Immediate effects of submaximal effort on pulse wave velocity in patients with Marfan syndrome

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dc.contributor.authorPeres, Paulo Alberto [UNIFESP]
dc.contributor.authorBernardelli, Graziella França [UNIFESP]
dc.contributor.authorMendes, Cássia Claudino [UNIFESP]
dc.contributor.authorFischer, Sven C P M [UNIFESP]
dc.contributor.authorServantes, Denise Maria [UNIFESP]
dc.contributor.authorMedeiros, Wladimir Musetti [UNIFESP]
dc.contributor.authorCarvalho, Antonio Carlos [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:41:38Z
dc.date.available2015-06-14T13:41:38Z
dc.date.issued2010-04-01
dc.description.abstractMarfan syndrome (MS) is a dominant autosomal disease caused by mutations in chromosome 15, the locus controlling fibrillin 1 synthesis, and may exhibit skeletal, ocular, cardiovascular, and other manifestations. Pulse wave velocity (PWV) is used to measure arterial elasticity and stiffness and is related to the elastic properties of the vascular wall. Since the practice of exercise is limited in MS patients, it was of interest to analyze the acute effect of submaximal exercise on aortic distensibility using PWV and other hemodynamic variables in patients with MS with either mild or no aortic dilatation. PWV and physiological variables were evaluated before and after submaximal exercise in 33 patients with MS and 18 controls. PWV was 8.51 ± 0.58 at rest and 9.10 ± 0.63 m/s at the end of exercise (P = 0.002) in the group with MS and 8.07 ± 0.35 and 8.98 ± 0.56 m/s in the control group, respectively (P = 0.004). Comparative group analysis regarding PWV at rest and at the end of exercise revealed no statistically significant differences. The same was true for the group that used β-blockers and the one that did not. The final heart rate was 10% higher in the control group than in the MS group (P = 0.01). Final systolic arterial pressure was higher in the control group (P = 0.02). PWV in MS patients with mild or no aortic dilatation did not differ from the control group after submaximal effort.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Disciplina de Cardiologia
dc.description.affiliationUnifespUNIFESP, Disciplina de Cardiologia
dc.description.sourceSciELO
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent397-402
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2010007500021
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 43, n. 4, p. 397-402, 2010.
dc.identifier.doi10.1590/S0100-879X2010007500021
dc.identifier.fileS0100-879X2010000400011.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2010000400011
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/5691
dc.identifier.wosWOS:000276670300011
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectExerciseen
dc.subjectAortic elasticityen
dc.subjectPulse wave velocityen
dc.subjectMarfan syndromeen
dc.titleImmediate effects of submaximal effort on pulse wave velocity in patients with Marfan syndromeen
dc.typeinfo:eu-repo/semantics/article
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