The Putative Impact of Metabolic Health on Default Mode Network Activity and Functional Connectivity in Neuropsychiatric Disorders

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dc.contributor.authorCha, Danielle S.
dc.contributor.authorDe Michele, Francesco
dc.contributor.authorSoczynska, Joanna K.
dc.contributor.authorWoldeyohannes, Hanna O.
dc.contributor.authorKaidanovich-Beilin, Oksana
dc.contributor.authorCarvalho, Andre F.
dc.contributor.authorMalhi, Gin S.
dc.contributor.authorPatel, Hiren
dc.contributor.authorSim, Kang
dc.contributor.authorBrietzke, Elisa [UNIFESP]
dc.contributor.authorMansur, Rodrigo Barbachan [UNIFESP]
dc.contributor.authorDunlop, Katharine A. M.
dc.contributor.authorAlsuwaidan, Mohammad
dc.contributor.authorBaskaran, Anusha
dc.contributor.authorFagiolini, Andrea
dc.contributor.authorReznikov, Roman
dc.contributor.authorKudlow, Paul A.
dc.contributor.authorMcIntyre, Roger S.
dc.contributor.institutionUniv Hlth Network
dc.contributor.institutionUniv Toronto
dc.contributor.institutionUniv Roma La Sapienza
dc.contributor.institutionMt Sinai Hosp
dc.contributor.institutionUniv Fed Ceara
dc.contributor.institutionUniv Sydney
dc.contributor.institutionCtr Addict & Mental Hlth
dc.contributor.institutionNatl Univ Singapore
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionQueens Univ
dc.contributor.institutionUniv Siena
dc.contributor.institutionUniv Western Ontario
dc.date.accessioned2018-06-15T17:05:06Z
dc.date.available2018-06-15T17:05:06Z
dc.date.issued2014-01-01
dc.description.abstractThe default mode network (DMN) describes a distributed network of brain regions that are predominantly activated and engaged during periods of spontaneous, stimulus independent thought (i.e., at rest) and remain quiescent during attention-demanding, goal-directed tasks. Replicated evidence in functional neuroimaging studies suggests that midline cortical and subcortical brain regions responsible for memory, self-relevant emotional and mental processes, as well as information integration comprise the DMN. The DMN is posited to represent self-referential mental activity via a dynamic interplay of cognitive and emotional processes by integrating information from the external environment with introspective thoughts to generate an autobiographical concept of the self.It has been amply documented that irregularities in the DMN and its functional connectivity are associated with various neuropsychiatric disorders. Moreover, accumulating evidence also suggests that individuals with select medical disorders (i.e., metabolic disorders) demonstrate alterations in DMN activity and functional connectivity. However, there is a paucity of data evaluating whether individuals with metabolically-based medical conditions, exhibiting altered DMN activity and functional connectivity, are at increased risk for developing neuropsychiatric disorders. Likewise, potential mechanisms (e.g., altered brain metabolism, insulin resistance) mediating these changes and their implications for novel treatment approaches have yet to be elucidated. Taken together, the overarching aim of this review is to provide a synthetic overview that suggests that this neural circuit may represent a common (or convergent) substrate affected in individuals with select neuropsychiatric and metabolic disorders.en
dc.description.affiliationUniv Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON M5T 2S8, Canada
dc.description.affiliationUniv Toronto, Inst Med Sci, Toronto, ON, Canada
dc.description.affiliationUniv Roma La Sapienza, Dept Neurol & Psychiat, I-00185 Rome, Italy
dc.description.affiliationMt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
dc.description.affiliationUniv Fed Ceara, Fac Med, Dept Clin Med, Fortaleza, Ceara, Brazil
dc.description.affiliationUniv Fed Ceara, Fac Med, Psychaitry Res Grp, Fortaleza, Ceara, Brazil
dc.description.affiliationUniv Sydney, CADE Clin, Dept Psychiat, Sydney, NSW 2006, Australia
dc.description.affiliationUniv Sydney, Adv Res High Field Imaging Facil, Sydney Med Sch Northern, Sydney, NSW 2006, Australia
dc.description.affiliationCtr Addict & Mental Hlth, Toronto, ON, Canada
dc.description.affiliationNatl Univ Singapore, Yong Loo Lin Sch Med, Inst Mental Hlth, Singapore 117595, Singapore
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychiat, LINC, Sao Paulo, Brazil
dc.description.affiliationUniv Toronto, Dept Psychiat, Toronto, ON, Canada
dc.description.affiliationQueens Univ, Ctr Neurosci Studies, Kingston, ON, Canada
dc.description.affiliationUniv Siena, Dept Mental Hlth, I-53100 Siena, Italy
dc.description.affiliationUniv Siena, Dept Mol Med, I-53100 Siena, Italy
dc.description.affiliationUniv Western Ontario, Schulich Sch Med & Dent, London, ON, Canada
dc.description.affiliationUniv Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychiat, LINC, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1750-1758
dc.identifierhttps://dx.doi.org/10.2174/1871527313666141130205024
dc.identifier.citationCns & Neurological Disorders-drug Targets. Sharjah: Bentham Science Publ Ltd, v. 13, n. 10, p. 1750-1758, 2014.
dc.identifier.doi10.2174/1871527313666141130205024
dc.identifier.issn1871-5273
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43397
dc.identifier.wosWOS:000348594400012
dc.language.isoeng
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCns & Neurological Disorders-drug Targets
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectDefault mode networken
dc.subjectfunctional connectivityen
dc.subjectmental disorderen
dc.subjectmood disorderen
dc.subjectneurological disorderen
dc.subjectneuropsychiatric disorderen
dc.subjectresting state networken
dc.subjectpsychiatric disorderen
dc.subjecttask negative networken
dc.titleThe Putative Impact of Metabolic Health on Default Mode Network Activity and Functional Connectivity in Neuropsychiatric Disordersen
dc.typeinfo:eu-repo/semantics/article
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