Decoherence in yeast cell populations and its implications for genome-wide expression noise

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dc.contributor.authorBriones, Marcelo Ribeiro da Silva [UNIFESP]
dc.contributor.authorBosco, Francisco [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T17:30:21Z
dc.date.available2018-06-15T17:30:21Z
dc.date.issued2009-01-01
dc.description.abstractGene expression noise is commonly defined as the stochastic variation of gene expression levels in different cells of the same population under identical growth conditions. Here, we tested whether this noise is amplified with time, as a consequence of decoherence in global gene expression profiles (genome-wide microarrays) of synchronized cells. The stochastic component of transcription causes fluctuations that tend to be amplified as time progresses, leading to a decay of correlations of expression profiles, in perfect analogy with elementary relaxation processes. Measuring decoherence, defined here as a decay in the auto-correlation function of yeast genome-wide expression profiles, we found a slowdown in the decay of correlations, opposite to what would be expected if, as in mixing systems, correlations decay exponentially as the equilibrium state is reached. Our results indicate that the populational variation in gene expression (noise) is a consequence of temporal decoherence, in which the slow decay of correlations is a signature of strong interdependence of the transcription dynamics of different genes.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Microbiol Imunol & Parasitol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Microbiol Imunol & Parasitol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipHoward Hughes Medical Institute
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent47-51
dc.identifierhttp://dx.doi.org/10.4238/vol8-1gmr531
dc.identifier.citationGenetics And Molecular Research. Ribeirao Preto: Funpec-editora, v. 8, n. 1, p. 47-51, 2009.
dc.identifier.doi10.4238/vol8-1gmr531
dc.identifier.fileWOS000265578600006.pdf
dc.identifier.issn1676-5680
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43723
dc.identifier.wosWOS:000265578600006
dc.language.isoeng
dc.publisherFunpec-editora
dc.relation.ispartofGenetics And Molecular Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDecoherenceen
dc.subjectGene expression noiseen
dc.subjectTranscriptionen
dc.subjectCell biologyen
dc.subjectBiophysicsen
dc.subjectMathematical biologyen
dc.titleDecoherence in yeast cell populations and its implications for genome-wide expression noiseen
dc.typeinfo:eu-repo/semantics/article
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