High oxygen extraction and slow recovery of muscle deoxygenation kinetics after neuromuscular electrical stimulation in COPD patients

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dc.citation.issue10
dc.citation.volume116
dc.contributor.authorAzevedo, Diego de Paiva
dc.contributor.authorMedeiros, Wladimir Musetti [UNIFESP]
dc.contributor.authorManfredi de Freitas, Flavia Fernandes
dc.contributor.authorAmorim, Cesar Ferreira
dc.contributor.authorGimenes, Ana Cristina Oliveira [UNIFESP]
dc.contributor.authorNeder, Jose Alberto [UNIFESP]
dc.contributor.authorChiavegato, Luciana Dias [UNIFESP]
dc.coverageNew York
dc.date.accessioned2020-07-31T12:47:41Z
dc.date.available2020-07-31T12:47:41Z
dc.date.issued2016
dc.description.abstractIt was hypothesized that patients with chronic obstructive pulmonary disease (COPD) would exhibit a slow muscle deoxygenation (HHb) recovery time when compared with sedentary controls. Neuromuscular electrical stimulation (NMES 40 and 50 mA, 50 Hz, 400 A mu s) was employed to induce isometric contraction of the quadriceps. Microvascular oxygen extraction (A mu O2EF) and HHb were estimated by near-infrared spectroscopy (NIRS). Recovery kinetic was characterized by measuring the time constant Tau (HHb-tau). Torque and work were measured by isokinetic dynamometry in 13 non-hypoxaemic patients with moderate-to-severe COPD [SpO(2) = 94.1 +/- 1.6 %en
dc.description.abstractFEV1 (% predict) 48.0 +/- 9.6en
dc.description.abstractGOLD II-III] and 13 age- and sex-matched sedentary controls. There was no desaturation in either group during NMES. Torque and work were reduced in COPD versus control for 40 and 50 mA [torque (Nm) 50 mA = 28.9 +/- 6.9 vs 46.1 +/- 14.2en
dc.description.abstractwork (J) 50 mA = 437.2 +/- 130.0 vs. 608.3 +/- 136.8en
dc.description.abstractP < 0.05 for all]. High A mu O2EF values were observed in the COPD group at both NMES intensities (corrected by muscle mass 50 mA = 6.18 +/- 1.1 vs. 4.68 +/- 1.0 %/kgen
dc.description.abstractcorrected by work 50 mA = 0.12 +/- 0.05 vs. 0.07 +/- 0.02 %/Jen
dc.description.abstractP < 0.05 for all). Absolute values of HHb-tau (50 mA = 31.11 +/- 9.27 vs. 18.08 +/- 10.70 s), corrected for muscle mass (50 mA 3.80 +/- 1.28 vs. 2.05 +/- 1.45 s/kg) and corrected for work (50 mA = 0.08 +/- 0.04 vs. 0.03 +/- 0.02 s/J) were reduced in COPD (P < 0.05 for all). The variables behaviour for 40 mA was similar to those of 50 mA. COPD patients exhibited a slower muscle deoxygenation recovery time after NMES. The absence of desaturation, low torque and work, high A mu O2EF and high values for recovery time corrected by muscle mass and work suggest that intrinsic muscle dysfunction has an impact on muscle recovery capacity.en
dc.description.affiliationUniv Sao Paulo UNICID, Masters & Doctoral Program Phys Therapy, Sao Paulo, SP, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Div Resp Med, Pulm Funct & Clin Exercise Physiol Unit, Rua Prof Francisco de Castro 54, BR-04020050 Sao Paulo, Brazil
dc.description.affiliationUnifespPulmonary Function and Clinical Exercise Physiology Unit, Division of Respiratory Medicine, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1899-1910
dc.identifierhttp://dx.doi.org/10.1007/s00421-016-3442-7
dc.identifier.citationEuropean Journal Of Applied Physiology. New York, v. 116, n. 10, p. 1899-1910, 2016.
dc.identifier.doi10.1007/s00421-016-3442-7
dc.identifier.issn1439-6319
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57008
dc.identifier.wosWOS:000384213500004
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofEuropean Journal Of Applied Physiology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectLung diseaseen
dc.subjectSkeletal muscleen
dc.subjectDeoxyhaemoglobinen
dc.subjectOxygen consumptionen
dc.subjectMetabolismen
dc.subjectExerciseen
dc.titleHigh oxygen extraction and slow recovery of muscle deoxygenation kinetics after neuromuscular electrical stimulation in COPD patientsen
dc.typeinfo:eu-repo/semantics/article
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