ATZ (3-amino-1,2,4-triazole) injected into the fourth cerebral ventricle influences the Bezold-Jarisch reflex in conscious rats

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dc.contributor.authorValenti, Vitor Engrácia [UNIFESP]
dc.contributor.authorAbreu, Luiz Carlos de
dc.contributor.authorSato, Monica A.
dc.contributor.authorFerreira, Celso [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFaculdade de Medicina do ABC Departamento de Morfologia e Fisiologia
dc.date.accessioned2015-06-14T13:41:30Z
dc.date.available2015-06-14T13:41:30Z
dc.date.issued2010-01-01
dc.description.abstractOBJECTIVES: Many studies have investigated the importance of oxidative stress on the cardiovascular system. In this study we evaluated the effects of central catalase inhibition on cardiopulmonary reflex in conscious Wistar rats. METHODS: Male Wistar rats were implanted with a stainless steel guide cannula in the fourth cerebral ventricle. The femoral artery and vein were cannulated for mean arterial pressure and heart rate measurement and for drug infusion, respectively. After basal mean arterial pressure and heart rate recordings, the cardiopulmonary reflex was tested with a dose of phenylbiguanide (PBG, 8 μg/kg, bolus). Cardiopulmonary reflex was evaluated before and μl15 minutes after 1.0 μl 3-amino-1,2,4-triazole (ATZ, 0.01g/100μl)0.01 g/100 μl) injection into the fourth cerebral ventricle. Vehicle treatment did not change cardiopulmonary reflex responses. RESULTS: Central ATZ significantly increased hypotensive responses without influencing the bradycardic reflex. CONCLUSION: ATZ injected into the fourth cerebral ventricle increases sympathetic inhibition but does not change the parasympathetic component of the cardiopulmonary reflex in conscious Wistar rats.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Medicina, Disciplina de Cardiologia
dc.description.affiliationFaculdade de Medicina do ABC Departamento de Morfologia e Fisiologia
dc.description.affiliationUnifespUNIFESP, Depto. de Medicina, Disciplina de Cardiologia
dc.description.sourceSciELO
dc.format.extent1339-1343
dc.identifierhttp://dx.doi.org/10.1590/S1807-59322010001200018
dc.identifier.citationClinics. Faculdade de Medicina / USP, v. 65, n. 12, p. 1339-1343, 2010.
dc.identifier.doi10.1590/S1807-59322010001200018
dc.identifier.fileS1807-59322010001200018.pdf
dc.identifier.issn1807-5932
dc.identifier.scieloS1807-59322010001200018
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/5576
dc.identifier.wosWOS:000288493400018
dc.language.isoeng
dc.publisherFaculdade de Medicina / USP
dc.relation.ispartofClinics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectReflexen
dc.subjectOxidative Stressen
dc.subjectCatalaseen
dc.subjectMedulla Oblongataen
dc.subjectCardiovascular Systemen
dc.titleATZ (3-amino-1,2,4-triazole) injected into the fourth cerebral ventricle influences the Bezold-Jarisch reflex in conscious ratsen
dc.typeinfo:eu-repo/semantics/article
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