Cardiovascular responses to microinjection of L-glutamate into the NTS in AV3V-lesioned rats

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dc.contributor.authorVieira, A. A.
dc.contributor.authorColombari, E.
dc.contributor.authorDe Luca, L. A.
dc.contributor.authorColombari, DSD
dc.contributor.authorMenani, J. V.
dc.contributor.institutionUNESP
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:37:26Z
dc.date.available2016-01-24T12:37:26Z
dc.date.issued2004-10-29
dc.description.abstractThe excitatory amino acid L-glutamate injected into the nucleus of the solitary tract (NTS) in unanesthetized rats similar to peripheral chemoreceptor activation increases mean arterial pressure (MAP) and reduces heart rate. in this study, we investigated the effects of acute (I day) and chronic (15 days) electrolytic lesions of the preoptic-periventricular tissue surrounding the anteroventral third ventricle (AV3V region) on the pressor and bradycardic responses induced by injections of L-glutamate into the NTS or peripheral chemoreceptor activation in unanesthetized rats. Male Holtzman rats with sham or electrolytic AV3V lesions and a stainless steel cannula implanted into the NTS were used. Differently from the pressor responses (28 +/- 3 mm Hg) produced by injections into the NTS of sham-lesioned rats, L-glutamate (5 nmol/ 100 nl) injected into the NTS reduced MAP (-26 +/- 8 mm Hg) or produced no effect (2 7 turn Hg) in acute and chronic AV3V-lesioned rats, respectively. the bradycardia to L-glutamate into the NTS and the cardiovascular responses to chemoreflex activation with intravenous potassium cyanide or to baroreflex activation with intravenous phenylephrine or sodium nitroprusside were not modified by AV3V lesions. the results show that the integrity of the AV3V region is essential for the pressor responses to L-glutamate into the NTS but not for the pressor responses to chemoreflex activation, suggesting dissociation between the central mechanisms involved in these responses. (C) 2004 Elsevier B.V. All rights reserved.en
dc.description.affiliationUNESP, Dept Fisiol & Patol, Fac Odontol Araraquara, Sch Dent, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUNIFESP, EPM, Dept Physiol, São Paulo, Brazil
dc.description.affiliationUnifespUNIFESP, EPM, Dept Physiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent106-112
dc.identifierhttp://dx.doi.org/10.1016/j.brainres.2004.08.006
dc.identifier.citationBrain Research. Amsterdam: Elsevier B.V., v. 1025, n. 1-2, p. 106-112, 2004.
dc.identifier.doi10.1016/j.brainres.2004.08.006
dc.identifier.issn0006-8993
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/27984
dc.identifier.wosWOS:000224682700013
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectbaroreceptoren
dc.subjectchemoreceptoren
dc.subjectsolitary tracten
dc.subjecthypothalamusen
dc.subjecthypertensionen
dc.titleCardiovascular responses to microinjection of L-glutamate into the NTS in AV3V-lesioned ratsen
dc.typeinfo:eu-repo/semantics/article
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