Takayasu arteritis in a Brazilian multicentre study: children with a longer diagnosis delay than adolescents

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dc.contributor.authorClemente, Gleice [UNIFESP]
dc.contributor.authorHilário, Maria Odete Esteves [UNIFESP]
dc.contributor.authorLederman, Henrique Manoel [UNIFESP]
dc.contributor.authorSilva, C. A.
dc.contributor.authorSallum, A. M.
dc.contributor.authorCampos, L. M.
dc.contributor.authorSacchetti, S.
dc.contributor.authorSantos, M. C. dos
dc.contributor.authorFerriani, Virginia Paes Leme [UNIFESP]
dc.contributor.authorSztajnbok, F.
dc.contributor.authorGasparello, R.
dc.contributor.authorOliveira, S. Knupp
dc.contributor.authorLessa, M.
dc.contributor.authorBica, B.
dc.contributor.authorCavalcanti, A.
dc.contributor.authorRobazzi, T.
dc.contributor.authorBandeira, M.
dc.contributor.authorTerreri, Maria Teresa Ramos Ascensão [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionSanta Casa Misericordia Sao Paulo
dc.contributor.institutionUniversidade do Estado do Rio de Janeiro (UERJ)
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade Federal de Pernambuco (UFPE)
dc.contributor.institutionUniversidade Federal da Bahia (UFBA)
dc.contributor.institutionHosp Pequeno Principe
dc.date.accessioned2018-06-15T16:52:45Z
dc.date.available2018-06-15T16:52:45Z
dc.date.issued2014-05-01
dc.description.abstractObjective. To evaluate and compare demographic, clinical, laboratory and angiographic data of Brazilian children and adolescents with Takayasu's arteritis.Methods. In this Brazilian multicentre, retrospective study which included 10 paediatric rheumatology centres, we identified 71 children and adolescents with Takayasu's arteritis which were diagnosed before their 19th birthday. The patients' demographic, clinical, laboratorial and angiographic data were recorded. The participants were divided into two groups: children, defined by the WHO as younger than 10 years old (group 1: 36 patients) and adolescents, defined as individuals aged 10 to 19 years old (group 2: 35 patients). Features of both groups concerning disease manifestations were compared.Results. A total of 21 (58.3%) patients in group 1 and 30 (85.7%) patients in group 2 were girls (p=0.01). The mean age at disease onset, the mean time to diagnosis, and the mean follow-up time were 5.7 and 12.7, 1.8 and 0.7, 7.2 and 3.6 years, respectively, in groups 1 and 2 (p<0.001, 0.001 and <0.001). At initial evaluation, constitutional symptoms (77.5%) were the most predominant symptoms and decreased peripheral pulses (85.9%) was the most predominant clinical sign without differences between groups. The main laboratory findings were increased erythrocyte sedimentation rate followed by leukocytosis. Anaemia, thrombocytosis and higher platelet levels were significantly more frequent in group 1 (p=0.031, 0.001 and 0.018). Angiographic data were similar in both groups.Conclusion. Children presented more laboratory abnormalities but clinical and angio graphic characteristics were similar to those presented by the adolescents. Diagnosis delay is longer in younger patients.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Paediat, Div Paediat Rheumatol, BR-04022005 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Imaging Diagnost, BR-04022005 Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Childrens Hosp, Paediat Rheumatol Unit, BR-05508 Sao Paulo, Brazil
dc.description.affiliationSanta Casa Misericordia Sao Paulo, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo Ribeirao Preto, Fac Med, Sao Paulo, Brazil
dc.description.affiliationUniv Estado Rio De Janeiro, Rio De Janeiro, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Inst Paediat Martagao Gesteira, BR-21941 Rio De Janeiro, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Rheumatol Unit, BR-21941 Rio De Janeiro, Brazil
dc.description.affiliationUniv Fed Pernambuco, Unit Rheumatol, Recife, PE, Brazil
dc.description.affiliationUniv Fed Bahia, Salvador, BA, Brazil
dc.description.affiliationHosp Pequeno Principe, Curitiba, Parana, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Paediat, Div Paediat Rheumatol, BR-04022005 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Imaging Diagnost, BR-04022005 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extentS128-S133
dc.identifierhttp://www.clinexprheumatol.org/abstract.asp?a=7199
dc.identifier.citationClinical And Experimental Rheumatology. Pisa: Clinical & Exper Rheumatology, v. 32, n. 2, p. S128-S133, 2014.
dc.identifier.issn0392-856X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43338
dc.identifier.wosWOS:000337069400025
dc.language.isoeng
dc.publisherClinical & Exper Rheumatology
dc.relation.ispartofClinical And Experimental Rheumatology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectTakayasu arteritisen
dc.subjectvasculitisen
dc.subjectchilden
dc.subjectadolescenten
dc.subjectdiagnosisen
dc.subjectangiographyen
dc.titleTakayasu arteritis in a Brazilian multicentre study: children with a longer diagnosis delay than adolescentsen
dc.typeinfo:eu-repo/semantics/article
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