HTLV-I infection among relatives of patients with adult T-cell Leukemia/Lymphoma in Brazil: Analysis of infection transmission

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dc.contributor.authorBorducchi, Davimar Miranda Maciel [UNIFESP]
dc.contributor.authorOliveira, José Salvador Rodrigues de [UNIFESP]
dc.contributor.authorBordin, Jose Orlando [UNIFESP]
dc.contributor.authorKerbauy, José [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-18T10:54:49Z
dc.date.available2018-06-18T10:54:49Z
dc.date.issued1998-10-01
dc.description.abstractWe examined the presence of HTLV-I infection among 66 family members of 13 patients with well documented ATL to investigate the routes of HLTV-I transmission in a Southeast region of Brazil. HTLV-I infection was screened by an enzyme immunossay (ELISA) test and an repeatedly positive or indeterminate ELISA samples were further tested by a Western-Blot (WB) technique. Indeterminate and inconclusive WE samples were confirmed by a polymerase chain reaction (PCR). ELISA results showed that 40 (60.6%) individuals were not infected; 16 (24.2%) were positive; and 10 (15.2%) were undetermined. Among 16 ELISA positive subjects, 14 (87.5%) were confirmed to be positive by WE while 2 (12.5%) showed inconclusive results. Based on the laboratory data, questionnaire analysis, and family/epidemiological studies, we concluded that HTLV-I vertical transmission occurred in 6 of the 13 families. In 3 of these 6 families, the horizontal transmission also could be demonstrated. An isolated horizontal transmission was detected in one family, and in 6 families we did not find any infected family member. All HTLV-I-infected persons were clinically asymptomatic. The occurrence of an effective HTLV-I vertical transmission detected by the present study suggest that HTLV-I infection is endemic in the Southeast region of Brazil. Consistent with the modes of transmission, the HTLV-I antibody seroprevalence was greater in relatives of ATL patients than in the general blood donor Brazilian population (0.4%). In addition, the present data suggest that HTLV-I carries a high infectivity rate but a low virulence.en
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Disciplina Hematol & Hemoterapia, Hematol & Transfus Med Serv, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Disciplina Hematol & Hemoterapia, Hematol & Transfus Med Serv, BR-04023900 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent411-416
dc.identifierhttp://dx.doi.org/10.3109/10428199809059235
dc.identifier.citationLeukemia & Lymphoma. Reading: Harwood Acad Publ Gmbh, v. 31, n. 3-4, p. 411-416, 1998.
dc.identifier.doi10.3109/10428199809059235
dc.identifier.issn1042-8194
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44854
dc.identifier.wosWOS:000077390500019
dc.language.isoeng
dc.publisherHarwood Acad Publ Gmbh
dc.relation.ispartofLeukemia & Lymphoma
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectHTLV-I infectionen
dc.subjectATLen
dc.subjectroute of transmissionen
dc.titleHTLV-I infection among relatives of patients with adult T-cell Leukemia/Lymphoma in Brazil: Analysis of infection transmissionen
dc.typeinfo:eu-repo/semantics/article
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