Evaluation of the Antihypertensive Properties of Yellow Passion Fruit Pulp (Passiflora edulis Sims f. flavicarpa Deg.) in Spontaneously Hypertensive Rats

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dc.contributor.authorKonta, Eliziane Mieko
dc.contributor.authorAlmeida, Mara Ribeiro
dc.contributor.authorAmaral, Catia Lira do
dc.contributor.authorCastania Darin, Joana Darc
dc.contributor.authorRosso, Veridiana Vera de [UNIFESP]
dc.contributor.authorMercadante, Adriana Zerlotti
dc.contributor.authorGreggi Antunes, Lusania Maria
dc.contributor.authorPires Bianchi, Maria Lourdes
dc.contributor.institutionUniv Estadual Paulista UNESP
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2016-01-24T14:35:01Z
dc.date.available2016-01-24T14:35:01Z
dc.date.issued2014-01-01
dc.description.abstractVarious species of the genus Passiflora have been extensively used in traditional medicine as sedatives, anxiolytics, diuretics and analgesics. in the present study, after the identification and quantification of phytochemical compounds from yellow passion fruit pulp by liquid chromatography-photodiode array-mass spectrometry (HPLC-PDA-MS/MS), its antihypertensive effect was investigated on spontaneously hypertensive rats. Additionally, the renal function, evaluated by kidney/body weight, serum creatinine, proteinuria, urinary flow, reduced glutathione (GSH) levels and thiobarbituric acid-reactive substances (TBARS) and mutagenicity in bone marrow cells were assessed to evaluate the safety of passion fruit consumption. Yellow passion fruit pulp (5, 6 or 8g/kg b.w.) was administered by gavage once a day for 5 consecutive days. HLPC-PDA-MS/MS analysis revealed that yellow passion fruit pulp contains phenolic compounds, ascorbic acid, carotenoids and flavonoids. the highest dose of passion fruit pulp significantly reduced the systolic blood pressure, increased the GSH levels and decreased TBARS. There were no changes in renal function parameters or the frequency of micronuclei in bone marrow cells. in conclusion, the antihypertensive effect of yellow passion fruit pulp, at least in part, might be due to the enhancement of the antioxidant status. the exact mechanisms responsible by this effect need further investigation. Copyright (c) 2013 John Wiley & Sons, Ltd.en
dc.description.affiliationUniv Estadual Paulista UNESP, Dept Alimentos & Nutr, Fac Ciencia Farmaceut Araraquara, Araraquara, SP, Brazil
dc.description.affiliationUniv São Paulo, Dept Anal Clin Toxicol & Bromatol, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Biociencias, Santos, SP, Brazil
dc.description.affiliationUniv Campinas UNICAMP, Dept Ciencia Alimentos, Fac Engn Alimentos, Campinas, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Biociencias, Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.description.sponsorshipIDCNPq: 13071/2007-7pt
dc.description.sponsorshipIDFAPESP: 2006/61237-4pt
dc.description.sponsorshipIDFAPESP: 2005/595992-6pt
dc.format.extent28-32
dc.identifierhttps://dx.doi.org/10.1002/ptr.4949
dc.identifier.citationPhytotherapy Research. Hoboken: Wiley-Blackwell, v. 28, n. 1, p. 28-32, 2014.
dc.identifier.doi10.1002/ptr.4949
dc.identifier.issn0951-418X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/37220
dc.identifier.wosWOS:000329510400004
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofPhytotherapy Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectPassion fruiten
dc.subjectMicronucleien
dc.subjectCarotenoidsen
dc.subjectPhenolic compoundsen
dc.subjectHypertensionen
dc.subjectRenal functionen
dc.titleEvaluation of the Antihypertensive Properties of Yellow Passion Fruit Pulp (Passiflora edulis Sims f. flavicarpa Deg.) in Spontaneously Hypertensive Ratsen
dc.typeinfo:eu-repo/semantics/article
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