Randomized Trial Comparing Multilayer Amniotic Membrane Transplantation With Scleral and Corneal Grafts for the Treatment of Scleral Thinning After Pterygium Surgery Associated With Beta Therapy

Página do item simplificado
dc.contributor.authorFarias, Charles Costa de [UNIFESP]
dc.contributor.authorSterlenich, Telma [UNIFESP]
dc.contributor.authorSousa, Luciene Barbosa de [UNIFESP]
dc.contributor.authorVieira, Luiz Antonio [UNIFESP]
dc.contributor.authorGomes, José Álvaro Pereira [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T17:05:10Z
dc.date.available2018-06-15T17:05:10Z
dc.date.issued2014-11-01
dc.description.abstractPurpose: The aim of this study was to compare the use of multilayer amniotic membrane transplantation (AMT) with lamellar corneal transplantation (LCT) and lamellar scleral transplantation (LST) for the treatment of scleral thinning after pterygium surgery associated with beta therapy.Methods: Twenty-six eyes from 26 different patients with scleral thinning as a consequence of beta therapy after pterygium surgery were evaluated at the Federal University of Sao Paulo, Brazil. Ophthalmologic examination and ultrasound biomicroscopy were performed to assess scleral thinning before the transplant surgery and then repeated at 30, 90, and 180 days after surgery. An increase in scleral thickness, epithelialization of the ocular surface, and preservation of the ocular globe were the main outcome measures.Results: Irrespective of the surgical technique used (AMT, LCT, or LST), no clinical or statistical changes in corrected distance visual acuity were found in any of the patients during this study. The median preoperative scleral thickness was similar in all 3 groups: AMT = 0.45 mm, LST = 0.48 mm, and LCT = 0.52 mm (P = 0.257); however, 6 months after surgery, the median thickness in the AMT group (0.19) was significantly less than that of the LCT group (0.57) (P = 0.27) or the LST group (0.76) (P = 0.19). Epithelialization occurred in all the patients.Conclusions: LCT was the best option for the structural treatment of scleral thinning, followed by LST with a conjunctival flap. A high rate of reabsorption was found with AMT, which was the least effective of the 3 therapeutic options and should not be used for this condition.en
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Ophthalmol & Visual Sci, Ocular Surface Adv Ctr CASO, BR-04023062 Sao Paulo, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Ophthalmol & Visual Sci, Cornea & External Dis Unit, BR-04023062 Sao Paulo, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Ophthalmol & Visual Sci, Ocular Ultrasound Unit, BR-04023062 Sao Paulo, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Dept Ophthalmol & Visual Sci, Ocular Surface Adv Ctr CASO, BR-04023062 Sao Paulo, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Dept Ophthalmol & Visual Sci, Cornea & External Dis Unit, BR-04023062 Sao Paulo, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Dept Ophthalmol & Visual Sci, Ocular Ultrasound Unit, BR-04023062 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipMinistry of Education, Brasilia/DF, Brazil
dc.description.sponsorshipIDCAPES: 3413118
dc.description.sponsorshipIDMinistry of Education, Brasilia/DF, Brazil: 70040-020
dc.format.extent1197-1204
dc.identifierhttps://dx.doi.org/10.1097/ICO.0000000000000207
dc.identifier.citationCornea. Philadelphia: Lippincott Williams & Wilkins, v. 33, n. 11, p. 1197-1204, 2014.
dc.identifier.doi10.1097/ICO.0000000000000207
dc.identifier.issn0277-3740
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43429
dc.identifier.wosWOS:000343672300013
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofCornea
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectpterygiumen
dc.subjectscleraen
dc.subjectcorneaen
dc.subjectamnionen
dc.subjecttransplantationen
dc.titleRandomized Trial Comparing Multilayer Amniotic Membrane Transplantation With Scleral and Corneal Grafts for the Treatment of Scleral Thinning After Pterygium Surgery Associated With Beta Therapyen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos