Effects of environmental enrichment and paradoxical sleep deprivation on open-field behavior of amphetamine-treated mice

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dc.contributor.authorFukushiro, Daniela Fukue [UNIFESP]
dc.contributor.authorCalzavara, Mariana Bendlin [UNIFESP]
dc.contributor.authorTrombin, Thaís Fernanda [UNIFESP]
dc.contributor.authorLopez, Giorgia Batlle [UNIFESP]
dc.contributor.authorAbilio, Vanessa Costhek [UNIFESP]
dc.contributor.authorAndersen, Monica Levy [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorFrussa-Filho, Roberto [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:49:13Z
dc.date.available2016-01-24T13:49:13Z
dc.date.issued2007-11-23
dc.description.abstractBackground: Environmental enrichment or paradoxical sleep deprivation (PSD) has been shown to modify some responses elicited by drugs of abuse. the aims of the present study were to examine the effects of environmental enrichment and PSD, conducted separately or in association, on open-field behavior elicited by amphetamine (AMP) in mice.Methods: Male C57BL/6 mice were randomly assigned to live in either an enriched environmental condition (EC) or a standard environmental condition (SC) for 12 months since weaning. Some of the EC and SC mice were sleep deprived for 48 h, while others were maintained in their home-cages. Immediately after PSD or home-cage stay, the animals received an ip injection of saline, 2.5 mg/kg AMP or 5.0 mg/kg AMP. Fifteen minutes later, their open-field behavior was quantified.Results: Whereas PSD enhanced total and peripheral locomotor activity of acutely AMP-treated mice, environmental enrichment presented only a trend toward enhancement. When PSD and environmental enrichment were combined, an increase in the total and peripheral locomotion frequencies of AMP-treated animals, similar to that observed after PSD, was revealed. in addition, PSD, environmental enrichment or their combination did not modify the effects of AMP on the other open-field behavioral parameters that were analyzed.Conclusion: the present findings demonstrate that some (but not all) of the behavioral effects caused by AMP acute administration can be similarly and specifically enhanced by both environmental enrichment and PSD in C57BL/6 mice. (C) 2007 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent773-779
dc.identifierhttps://dx.doi.org/10.1016/j.physbeh.2007.06.002
dc.identifier.citationPhysiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 92, n. 4, p. 773-779, 2007.
dc.identifier.doi10.1016/j.physbeh.2007.06.002
dc.identifier.issn0031-9384
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/30153
dc.identifier.wosWOS:000251409300029
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPhysiology & Behavior
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectEnvironmental enrichmenten
dc.subjectParadoxical sleep deprivationen
dc.subjectAmphetamineen
dc.subjectOpen-field behavioren
dc.subjectC57BL/6 miceen
dc.titleEffects of environmental enrichment and paradoxical sleep deprivation on open-field behavior of amphetamine-treated miceen
dc.typeinfo:eu-repo/semantics/article
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