The relationship of the active and latent forms of TGF-beta 1 with marrow fibrosis in essential thrombocythemia and primary myelofibrosis

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dc.contributor.authorPonce, Cesar Cilento [UNIFESP]
dc.contributor.authorChauffaille, Maria de Lourdes F. [UNIFESP]
dc.contributor.authorIhara, Silvia Saiuli M. [UNIFESP]
dc.contributor.authorSilva, Maria Regina R. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:28:04Z
dc.date.available2016-01-24T14:28:04Z
dc.date.issued2012-12-01
dc.description.abstractThe aim of this study was to perform an immunohistochemical analysis from 100 megakaryocytes per sample, analyzing positivity and intensity levels of anti-LAP human TGF-beta 1 (or Latent TGF-beta 1) and anti-TGF-beta 1 (or Active TGF-beta 1) antibodies from 18 essential thrombocythemia (ET) and 38 primary myelofibrosis (PMF) patients (being 19 pre-fibrotic and 19 fibrotic). Six bone marrow donor biopsies were used as controls. Fibrosis in bone marrow biopsies (BMB) was evaluated according to the European Consensus. the average fibrosis grade differed between each group (P = 0.001 or P = 0.003). Latent TGF-beta 1 values differed significantly between pre-fibrotic (P = 0.018) and fibrotic (P = 0.031) groups when compared with the control group. the high immunoexpression level of Latent TGF-beta 1 in the megakaryocytes from patients with myelofibrosis, which was not observed in patients with essential thrombocythemia, may be associated with the development of bone marrow fibrosis.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pathol, BR-11045501 São Paulo, Santos, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Hematol, BR-11045501 São Paulo, Santos, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pathol, BR-11045501 São Paulo, Santos, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Hematol, BR-11045501 São Paulo, Santos, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 07-55948-8
dc.format.extent2337-2344
dc.identifierhttp://dx.doi.org/10.1007/s12032-011-0144-1
dc.identifier.citationMedical Oncology. Totowa: Humana Press Inc, v. 29, n. 4, p. 2337-2344, 2012.
dc.identifier.doi10.1007/s12032-011-0144-1
dc.identifier.issn1357-0560
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35546
dc.identifier.wosWOS:000309711600005
dc.language.isoeng
dc.publisherHumana Press Inc
dc.relation.ispartofMedical Oncology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectLatent TGF-beta 1en
dc.subjectActive TGF-beta 1en
dc.subjectMegakaryocytesen
dc.subjectPrimary myelofibrosisen
dc.subjectEssential thrombocythemiaen
dc.subjectImmunohistochemistryen
dc.subjectFibrosisen
dc.titleThe relationship of the active and latent forms of TGF-beta 1 with marrow fibrosis in essential thrombocythemia and primary myelofibrosisen
dc.typeinfo:eu-repo/semantics/article
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