Cystatin C and renal function in pediatric kidney transplant recipients

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dc.contributor.authorFranco, Maria do Carmo Pinho [UNIFESP]
dc.contributor.authorNagasako, Samantha Santiago [UNIFESP]
dc.contributor.authorMachado, Paula Goulart Pinheiro [UNIFESP]
dc.contributor.authorNogueira, Paulo Cesar Koch [UNIFESP]
dc.contributor.authorPestana, Jose Osmar Medina [UNIFESP]
dc.contributor.authorSesso, Ricardo de Castro Cintra [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:41:17Z
dc.date.available2015-06-14T13:41:17Z
dc.date.issued2009-12-01
dc.description.abstractIn clinical practice, the glomerular filtration rate (GFR) is often determined with serum creatinine. However, studies have shown cystatin C to be a better parameter for the diagnosis of impaired renal function. We compared GFR estimated by plasma cystatin C with GFR estimated by serum creatinine in a sample of 50 pediatric renal transplant recipients and 24 healthy children. The correlation between GFR estimated by serum creatinine and by cystatin C was significant (r = 0.75; P < 0.001, Person’s correlation); however, in pediatric kidney transplant recipients, the GFR was 6.7 mL/min lower when determined using cystatin C rather than serum creatinine. Moreover, using GFR estimated by cystatin C we found that 42% of the pediatric kidney transplant recipients had an estimated GFR <60 mL·min-1·1.73 (m²)-1, whereas when GFR was estimated by the serum creatinine formula only 16% of the children had values below this cutoff point indicative of chronic kidney disease (P < 0.001). We conclude that, in pediatric kidney transplant recipients, estimation of GFR yields lower values when cystatin C is used rather than serum creatinine.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Medicina Disciplina de Nefrologia
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Pediatria
dc.description.affiliationUnifespUNIFESP, Depto. de Medicina Disciplina de Nefrologia
dc.description.affiliationUnifespUNIFESP, Depto. de Pediatria
dc.description.sourceSciELO
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 04/10342-7
dc.format.extent1225-1229
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2009007500003
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 42, n. 12, p. 1225-1229, 2009.
dc.identifier.doi10.1590/S0100-879X2009007500003
dc.identifier.fileS0100-879X2009001200017.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2009001200017
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/5366
dc.identifier.wosWOS:000272487500017
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChildrenen
dc.subjectKidney transplanten
dc.subjectCystatin Cen
dc.subjectCreatinineen
dc.subjectGlomerular filtration rateen
dc.titleCystatin C and renal function in pediatric kidney transplant recipientsen
dc.typeinfo:eu-repo/semantics/article
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