Changes in cat urinary glycosaminoglycans with age and in feline urologic syndrome

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dc.contributor.authorPereira, D. A.
dc.contributor.authorAguiar, JAK
dc.contributor.authorHagiwara, M. K.
dc.contributor.authorMichelacci, Y. M.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T12:37:06Z
dc.date.available2016-01-24T12:37:06Z
dc.date.issued2004-04-07
dc.description.abstractThe aim of the present study was to characterize the urinary excretion of glycosaminoglycaris in kittens and adult healthy cats, as well as in cats with a low urinary tract disease, the feline urologic syndrome (FUS). the main urinary glycosamitioglycan in cats was found to be chondroitin sulfate, with smaller amounts of dermatan sulfate and heparan sulfate. There was no difference in the urinary glycosaminoglycan concentration with sex, but a marked decrease occurred with age, due to chondroitin sulfate. Trace amounts of keratan sulfate were also detected in the urine of kittens, but not of healthy adult cats. Dermatan sulfate and heparan sulfate were the only glycosaminoglycans found in the urinary tract and kidney, and chondroitin sulfate was the only glycosaminoglycan found in the plasma. These data suggest that the main urinary glycosaminoglycan chondroitin sulfate is of systemic origin and filtered in the kidney, while the minor components dermatan sulfate and heparan sulfate may come from the urinary tract. the urinary glycosaminoglycan concentration was greatly decreased in animals with FUS, as compared to normal adults. We hypothesize that these low glycosaminoglycan levels reflect a damage to the bladder surface, resulting in absorption and/or degradation of the endogenous urinary glycosaminoglycans. (C) 2004 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, EPM, Dept Bioquim, BR-04044020 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Vet & Zootecnia, Dept Clin Med, BR-05508 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, EPM, Dept Bioquim, BR-04044020 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1-11
dc.identifierhttp://dx.doi.org/10.1016/j.bbagen.2004.02.002
dc.identifier.citationBiochimica Et Biophysica Acta-general Subjects. Amsterdam: Elsevier B.V., v. 1672, n. 1, p. 1-11, 2004.
dc.identifier.doi10.1016/j.bbagen.2004.02.002
dc.identifier.issn0304-4165
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/27707
dc.identifier.wosWOS:000220735600001
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBiochimica Et Biophysica Acta-general Subjects
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectcaten
dc.subjectglycosaminoglycanen
dc.subjecturineen
dc.subjecturinary tracten
dc.subjectkidneyen
dc.subjectfeline urologic syndromeen
dc.titleChanges in cat urinary glycosaminoglycans with age and in feline urologic syndromeen
dc.typeinfo:eu-repo/semantics/article
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