Grape juice concentrate modulates p16 expression in high fat diet-induced liver steatosis in Wistar rats

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dc.contributor.authorFerreira, Andressa Orlandeli [UNIFESP]
dc.contributor.authorBoiago Golluecke, Andrea Pittelli
dc.contributor.authorNoguti, Juliana [UNIFESP]
dc.contributor.authorPereira da Silva, Victor Hugo [UNIFESP]
dc.contributor.authorHojo Yamamura, Elsa Tiemi
dc.contributor.authorRibeiro, Daniel Araki [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Catolica Santos
dc.date.accessioned2016-01-24T14:27:06Z
dc.date.available2016-01-24T14:27:06Z
dc.date.issued2012-04-01
dc.description.abstractPurpose: the goal of this study was to investigate whether subchronic treatment with grape juice concentrate is able to protect the liver from high fat diet injury in rats. the effects of grape juice concentrate treatment on histopathological changes, and immunohistochemistry for p53, p16 and p21 were evaluated.Methods: Male Wistar rats (n = 18) were distributed into three groups: group 1: negative control; group 2: cholesterol at 1% (w/w) in their diet, treated during 5 weeks; and group 3: cholesterol at 1% in their chow during 5 weeks, and grape juice concentrate at 222 mg per day in their drinking-water in the last week only.Results: the results pointed out that treatment with grape juice concentrate did not show remarkable differences regarding liver tissue in the cholesterol-exposed group when compared to group 2. However, grape juice concentrate was able to modulate p16 immunoexpression when compared to high fat diet group. p53 and p21 did not show any significant statistical differences among groups.Conclusion: Taken together, our results suggest that subchronic grape juice concentrate administration was able to modulate cell cycle control by downregulation of p16 immunoexpression in high fat diet-induced liver steatosis in rats.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biociencias, Santos, Brazil
dc.description.affiliationUniv Catolica Santos, HEXALAB, Santos, Brazil
dc.description.affiliationUniv Catolica Santos, Dept Nutr, Santos, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Paulista Med Sch, Dept Pathol, Santos, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biociencias, Santos, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Paulista Med Sch, Dept Pathol, Santos, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent218-224
dc.identifierhttp://dx.doi.org/10.3109/15376516.2011.631196
dc.identifier.citationToxicology Mechanisms and Methods. London: Informa Healthcare, v. 22, n. 3, p. 218-224, 2012.
dc.identifier.doi10.3109/15376516.2011.631196
dc.identifier.issn1537-6516
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34790
dc.identifier.wosWOS:000300254700007
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofToxicology Mechanisms and Methods
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.subjectCholesterol dieten
dc.subjectratsen
dc.subjectgrape juiceen
dc.subjectp53en
dc.subjectp16en
dc.subjectp21en
dc.titleGrape juice concentrate modulates p16 expression in high fat diet-induced liver steatosis in Wistar ratsen
dc.typeinfo:eu-repo/semantics/article
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