Characterization of the rapid-onset type of behavioral sensitization to amphetamine in mice: Role of drug-environment conditioning
| dc.contributor.author | Chinen, Cibele Cristina | |
| dc.contributor.author | Faria, Rulian Ricardo | |
| dc.contributor.author | Frussa-Filho, Roberto [UNIFESP] | |
| dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
| dc.date.accessioned | 2016-01-24T12:38:13Z | |
| dc.date.available | 2016-01-24T12:38:13Z | |
| dc.date.issued | 2006-01-01 | |
| dc.description.abstract | A rapid-onset type of behavioral sensitization (ROBS) has been demonstrated in rats treated with a single 'priming' injection of amphetamine (AMP). in that species, however, this phenomenon was restricted to AMP-induced stereotyped behavior (SB), not occurring for the locomotor-stimulant effect (LSE) of AMP and not reflecting environment-specific sensitization. in the present study, the ROBS was characterized in the mouse. Mice received a single 'priming' intraperitoneal injection of 5.0 mg/kg AMP which was paired or not with environment. At different intervals (3, 4 or 5 h) subgroups were tested for AMP (1.5 or 5.0 mg/kg)-induced SB or AMP (1.5 mg/kg)-induced open-field LSE. Results showed that: (1) in the absence of drug-environment association, a priming injection of AMP increased the SB induced by a 1.5 mg/kg AMP challenge injection given 3 h (but not 4 or 5 h) later; (2) when the dose of AMP challenge injection was increased to 5.0 mg/kg, an enhancement of SB was verified at all the intervals tested (3, 4, and 5 h); (3) when animals were tested in an open field, the priming injection of AMP produced an increase in the LSE of a 1.5 mg/kg AMP challenge injection, given 4 h later; (4) drug-environment association increased both SB and locomotion after a saline challenge injection and potentiated the rapid-onset sensitization of both behaviors in AMP-challenged mice. Collectively, these results demonstrate that the ROBS phenomenon also occurs in mice, is extended to AMP-induced LSE, and is markedly potentiated by (but does not depend on) environmental conditioning. | en |
| dc.description.affiliation | Universidade Federal de São Paulo, Escola Paulista Med, Dept Farmacol, BR-04023062 São Paulo, Brazil | |
| dc.description.affiliationUnifesp | Universidade Federal de São Paulo, Escola Paulista Med, Dept Farmacol, BR-04023062 São Paulo, Brazil | |
| dc.description.source | Web of Science | |
| dc.format.extent | 151-159 | |
| dc.identifier | http://dx.doi.org/10.1038/sj.npp.1300789 | |
| dc.identifier.citation | Neuropsychopharmacology. London: Nature Publishing Group, v. 31, n. 1, p. 151-159, 2006. | |
| dc.identifier.doi | 10.1038/sj.npp.1300789 | |
| dc.identifier.issn | 0893-133X | |
| dc.identifier.uri | http://repositorio.unifesp.br/handle/11600/28602 | |
| dc.identifier.wos | WOS:000236132000014 | |
| dc.language.iso | eng | |
| dc.publisher | Nature Publishing Group | |
| dc.relation.ispartof | Neuropsychopharmacology | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | amphetamine | en |
| dc.subject | conditioning | en |
| dc.subject | stereotypy | en |
| dc.subject | locomotion | en |
| dc.subject | behavioral sensitization | en |
| dc.title | Characterization of the rapid-onset type of behavioral sensitization to amphetamine in mice: Role of drug-environment conditioning | en |
| dc.type | info:eu-repo/semantics/article |