Cox-2, EGFR, and ERBB-2 Expression in Cervical Intraepithelial Neoplasia and Cervical Cancer Using an Automated Imaging System

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dc.contributor.authorFukazawa, Elza M.
dc.contributor.authorBaiocchi, Glauco
dc.contributor.authorSoares, Fernando A.
dc.contributor.authorKumagai, Lillian Y.
dc.contributor.authorFaloppa, Carlos C.
dc.contributor.authorBadiglian-Filho, Levon
dc.contributor.authorCoelho, Francisco R. G.
dc.contributor.authorGoncalves, Wagner Jose [UNIFESP]
dc.contributor.authorCosta, Ronaldo L. R.
dc.contributor.authorGoes, Joao C. S.
dc.contributor.institutionAC Camargo Canc Hosp
dc.contributor.institutionBrazilian Inst Canc Control
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:37:16Z
dc.date.available2016-01-24T14:37:16Z
dc.date.issued2014-05-01
dc.description.abstractWe hypothesized that the activation of cyclooxygenase (COX)-2, epidermal growth factor receptor (EGFR), and ErbB-2 signaling is required for cervical intraepithelial neoplasia (CIN) lesions to progress to cervical cancer. A retrospective analysis was performed in 179 patients with Stage I squamous cell carcinoma (SCC) and 233 patients with CIN (112 CIN I, 47 CIN II, and 74 CIN III). COX-2, EGFR, and ErbB-2 expression was analyzed by immunohistochemistry using the ACIS III automated imaging system. the mean expression of COX-2, EGFR, and ErbB-2 was compared between the various stages of CIN and SCC. COX-2 mean expression was predominantly cytoplasmic, increasing significantly from CIN I to CIN II, CIN III, and SCC (P < 0.001). EGFR mean expression also rose significantly during tumor progression from CIN I to SCC (P=0.001). CIN I samples were negative for ErbB-2 expression. CIN II, CIN III, and SCC were considered positive for ErbB-2 expression in 2.2%, 14%, and 16.2% of cases, respectively. There was also a statistically significant correlation between increase of ErbB-2 positivity from CIN to SCC. We conclude that COX-2, EGFR, and ErbB-2 expression increase significantly during the progression of CIN to cancer.en
dc.description.affiliationAC Camargo Canc Hosp, Dept Gynecol Oncol, São Paulo, Brazil
dc.description.affiliationAC Camargo Canc Hosp, Dept Pathol, São Paulo, Brazil
dc.description.affiliationBrazilian Inst Canc Control, Dept Gynecol Oncol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Obstet & Gynecol, Discipline Gynecol Oncol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Obstet & Gynecol, Discipline Gynecol Oncol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent225-234
dc.identifierhttp://dx.doi.org/10.1097/PGP.0b013e318290405a
dc.identifier.citationInternational Journal of Gynecological Pathology. Philadelphia: Lippincott Williams & Wilkins, v. 33, n. 3, p. 225-234, 2014.
dc.identifier.doi10.1097/PGP.0b013e318290405a
dc.identifier.issn0277-1691
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37746
dc.identifier.wosWOS:000334474200003
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofInternational Journal of Gynecological Pathology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCyclooxygenase 2en
dc.subjectERBB-2en
dc.subjectEGFRen
dc.subjectUterine cervical neoplasmen
dc.subjectCervical intraepithelial neoplasiaen
dc.titleCox-2, EGFR, and ERBB-2 Expression in Cervical Intraepithelial Neoplasia and Cervical Cancer Using an Automated Imaging Systemen
dc.typeinfo:eu-repo/semantics/article
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