Acute systemic blockade of D2 receptors does not accelerate the extinction of cocaine-associated place preference

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dc.contributor.authorYim Júnior, Alberto [UNIFESP]
dc.contributor.authorAndersen, M. L. [UNIFESP]
dc.contributor.authorSoeiro, A. C. [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorOliveira, Maria Gabriela Menezes de [UNIFESP]
dc.contributor.institutionUniv Fed Tocantins
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:59:00Z
dc.date.available2016-01-24T13:59:00Z
dc.date.issued2009-12-04
dc.description.abstractFacilitation of extinction can be used as a therapeutic tool in treatment of both post-traumatic stress disorder and drug addiction. the present study examined whether the blockade of D2 receptors before each extinction trial would accelerate the extinction of cocaine-induced place preference. Male Wistar rats were initially conditioned and tested for a cocaine-associated place-preference (20 mg/kg). On the following day after the initial test, the animals were submitted to extinction training. This training consisted of daily sessions in which the subjects were alternatively confined during 30 min in the saline and cocaine-associated environment. However, 30 min before each extinction trial the animals received a systemic injection of D2 antagonist sulpiride. While one group was treated with a dose of 50 mg/kg (ip), the other group was treated with a dose of 100 mg/kg. An additional control group received injections of saline during extinction trials. Twenty-four hours after the last extinction trial, the animals were tested again for their preferences to cocaine and saline associated environments. Since one round of extinction trial was not sufficient to produce extinction of cocaine associated place preference, the animals were submitted to a second cycle of extinction trials and test. the systemic administration of the two doses of sulpiride (50 and 100 mg/kg) 30 min before each conditioning did not enhance the extinction of cocaine-associated place preference. This finding suggests that the D2 receptors are not involved in a acute protocol of extinction of cocaine-induced place preference. (C) 2009 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Tocantins, Fac Med Vet, BR-77804970 Araguaina, TO, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Psychobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundo de Amparo a Psicofarmacologia (AFIP)
dc.format.extent122-128
dc.identifierhttp://dx.doi.org/10.1016/j.brainres.2009.09.044
dc.identifier.citationBrain Research. Amsterdam: Elsevier B.V., v. 1304, p. 122-128, 2009.
dc.identifier.doi10.1016/j.brainres.2009.09.044
dc.identifier.issn0006-8993
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32016
dc.identifier.wosWOS:000272654400013
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectCocaineen
dc.subjectExtinctionen
dc.subjectSulpirideen
dc.subjectDopamineen
dc.subjectPlace preferenceen
dc.titleAcute systemic blockade of D2 receptors does not accelerate the extinction of cocaine-associated place preferenceen
dc.typeinfo:eu-repo/semantics/article
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