Immunophenotypic Profile and Increased Risk of Hospital Admission for Infection in Infants Born to Female Kidney Transplant Recipients
Data
2015-06-01
Autores
Ono, E. 
Santos, A. M. dos
Viana, P. O.
Dinelli, M. I. S.
Sass, N.
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Children born to female kidney recipients are exposed to immunosuppressive drugs during gestation. Little is known about their immune system at birth or in the long term. Twenty-eight children born to female kidney recipients and 40 full-term children born to healthy mothers were evaluated. T, B, NK, NKT, T cells were assessed by flow cytometry and functional evaluation of T and dendritic cells after in vitro activation was performed at birth and at 8 months of age. At birth, infants born to female kidney recipients showed lower numbers of CD4+ T, NKT and intense reduction of B cells (median cells/mm(3), transplant: 153.7 X control: 512.4; p<0.001). There was also a reduced percentage of activated CD8+ T and of CD4+ regulatory T cells. Activated memory and exhausted memory B cells showed higher percentages among children exposed to immunosuppressors when compared to control group. At 8 months, most immune alterations were no longer observed, but four children still had low numbers of some lymphocyte subsets at this age. Children born to female kidney recipients had 4.351 (95% CI: 1.026-15.225; p=0.046) higher risk of hospital admission in the first months of lifesome, with severe clinical manifestationsthan those born to healthy women.
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American Journal of Transplantation. Hoboken: Wiley-Blackwell, v. 15, n. 6, p. 1654-1665, 2015.