Performance of glycated haemoglobin (HbA1c) as a screening test for diabetes and impaired glucose tolerance (IGT) in a high risk population-The Brazilian Xavante Indians

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dc.contributor.authorFranco, L. J.
dc.contributor.authorDal Fabbro, A. L.
dc.contributor.authorMartinez, E. Z.
dc.contributor.authorSartorelli, D. S.
dc.contributor.authorSilva, A. S.
dc.contributor.authorSoares, L. P.
dc.contributor.authorFranco, L. F. [UNIFESP]
dc.contributor.authorKuhn, P. C. [UNIFESP]
dc.contributor.authorVieira-Filho, J. P. B. [UNIFESP]
dc.contributor.authorMoises, R. S. [UNIFESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:38:05Z
dc.date.available2016-01-24T14:38:05Z
dc.date.issued2014-11-01
dc.description.abstractAims: To examine the properties of HbA1c to detect diabetes and IGT in adult Brazilian Xavante Indians, a high risk population for diabetes.Methods: the survey was carried out between October 2010 and January 2012 and based on a 75 g oral glucose tolerance test (OGTT). Basal and 2 h capillary glycaemia were measured by HemoCue Glucose 201+; HbA1c using an automated high-performance liquid chromatography analyzer (Tosoh G7).Results: 630 individuals aged >20 years were examined and 80 had a previous diagnosis of diabetes. Sensitivity, specificity and accuracy for HbA1c >= 6.5% (>= 48 mmol/mol) were 71.3%, 90.5% and 87.2%. the areas under the ROC curve (AUC) was 0.88 (95%CI: 0.83-0.93). To identify IGT, HbA1c values between 5.7% and 6.4% (39-47 mmol/mol) presented sensitivity, specificity and accuracy of 87.2%, 24.7% and 51.4%, with an AUC of 0.62 (95%CI: 0.57-0.67).Conclusions: the ADA/WHO proposed cut-off of 6.5% (48 mmol/mol) for HbA1c was adequate to detect diabetes among the Xavante. However, the performance of the ADA proposed cutoff points for pre-diabetes, when used to detect IGT was inadequate and should not be recommended. (C) 2014 Elsevier Ireland Ltd. All rights reserved.en
dc.description.affiliationUniv São Paulo, Ribeirao Preto Med Sch, Dept Social Med, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Div Endocrinol, BR-04039001 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Div Endocrinol, BR-04039001 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent337-342
dc.identifierhttp://dx.doi.org/10.1016/j.diabres.2014.08.027
dc.identifier.citationDiabetes Research and Clinical Practice. Clare: Elsevier B.V., v. 106, n. 2, p. 337-342, 2014.
dc.identifier.doi10.1016/j.diabres.2014.08.027
dc.identifier.issn0168-8227
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38393
dc.identifier.wosWOS:000346060500033
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofDiabetes Research and Clinical Practice
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectDiabetes mellitusen
dc.subjectImpaired glucose toleranceen
dc.subjectHbA1cen
dc.subjectBrazilian Indiansen
dc.titlePerformance of glycated haemoglobin (HbA1c) as a screening test for diabetes and impaired glucose tolerance (IGT) in a high risk population-The Brazilian Xavante Indiansen
dc.typeinfo:eu-repo/semantics/article
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