Pulmonary function in former very low birth weight preterm infants in the first year of life

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dc.citation.volume136
dc.contributor.authorMiranda Goncalves, Daniela de Melo [UNIFESP]
dc.contributor.authorWandalsen, Gustavo Falbo [UNIFESP]
dc.contributor.authorScavacini, Ana Silvia [UNIFESP]
dc.contributor.authorLanza, Fernanda Cordoba [UNIFESP]
dc.contributor.authorGoulart, Ana Lucia [UNIFESP]
dc.contributor.authorSole, Dirceu [UNIFESP]
dc.contributor.authorNunes dos Santos, Amelia Miyashiro [UNIFESP]
dc.coverageLondon
dc.date.accessioned2020-07-08T13:09:30Z
dc.date.available2020-07-08T13:09:30Z
dc.date.issued2018
dc.description.abstractBackground: Pulmonary function in former preterm infants may be compromised during childhood. Objectives: To assess pulmonary function in very-low-birth-weight preterm infants at 6-12 months of corrected age and analyze the factors associated with abnormal pulmonary function. Methods: Cross-sectional study with preterm infants at 6-12 months of corrected age with birth weight < 1500 g. Children with malformations or affected by neuromuscular and respiratory diseases were excluded. Forced expiratory flows were assessed using the chest compression technique, and volumes were measured by total body plethysmography. Pulmonary function parameters in preterm infants were compared to a control group of same-aged children born at term. Results: We studied 51 preterm and 37 infants born at term. Preterm infants had: gestational age at birth ( 30.0 +/- 2.5 weeks), birth weight ( 1179 +/- 247 g), 27.5% had bronchopulmonary dysplasia, and 45% received mechanical ventilation. Preterm infants had lower median z-scores in comparison to term infants for the following parameters ( p < 0.05): FVC (-0.3 vs. 0.7), FEV0.5 (-0.5 vs. 0.9), FEV0.5/FVC (-0.6 vs. -0.5), FEF50 (-0.4 vs. 0.9), FEF75 (-0.3 vs. 0.8), FEF85 (-0.1 vs. 0.6) and FEF25-75 (-0.5 vs. 1.1). No term child had abnormal lung function, compared to 39.2% of preterm infants ( p=0.001). Factors associated with abnormal pulmonary function were lower gestational age at birth, small for gestational age, need for mechanical ventilation and presence of recurrent wheezing. Conclusions: Preterms had a high prevalence of abnormal pulmonary function and lower pulmonary function in comparison to term infants. Prematurity, intrauterine growth restriction, respiratory support and recurrent wheezing were associated with abnormal pulmonary function.en
dc.description.affiliationUniv Fed Sao Paulo, Neonatal Div Med, Dept Pediat, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Div Allergy Clin Immunol & Rheumatol, Dept Pediat, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Neonatal Div Med, Dept Pediat, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Div Allergy Clin Immunol & Rheumatol, Dept Pediat, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent83-87
dc.identifierhttp://dx.doi.org/10.1016/j.rmed.2018.02.004
dc.identifier.citationRespiratory Medicine. London, v. 136, p. 83-87, 2018.
dc.identifier.doi10.1016/j.rmed.2018.02.004
dc.identifier.issn0954-6111
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54052
dc.identifier.wosWOS:000426428800012
dc.language.isoeng
dc.publisherW B Saunders Co Ltd
dc.relation.ispartofRespiratory Medicine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectChilden
dc.subjectInfanten
dc.subjectPrematureen
dc.subjectPulmonary functionen
dc.subjectPlethysmographyen
dc.subjectRisk factorsen
dc.titlePulmonary function in former very low birth weight preterm infants in the first year of lifeen
dc.typeinfo:eu-repo/semantics/article
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