Assessment of working memory in patients with mesial temporal lobe epilepsy associated with unilateral hippocampal sclerosis

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dc.contributor.authorSilva Tudesco, Ivanda de Souza [UNIFESP]
dc.contributor.authorVaz, Leonardo Jose [UNIFESP]
dc.contributor.authorSilva Mantoan, Marcele Araujo [UNIFESP]
dc.contributor.authorBelzunces, Erich [UNIFESP]
dc.contributor.authorNoffs, Maria Helena [UNIFESP]
dc.contributor.authorSales Ferreira Caboclo, Luis Otavio [UNIFESP]
dc.contributor.authorTargas Yacubian, Elza Marcia [UNIFESP]
dc.contributor.authorSakamoto, Americo Ceiki [UNIFESP]
dc.contributor.authorAmodeo Bueno, Orlando Francisco [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:05:08Z
dc.date.available2016-01-24T14:05:08Z
dc.date.issued2010-07-01
dc.description.abstractObjective: the aim of the present study was to investigate whether working memory is impaired in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS), a controversial and largely unexplored matter.Methods: Twenty subjects with left MTLE-HS, 19 with right MTLE-HS, and 21 control right-handed subjects underwent neuropsychological assessment of episodic and semantic memory, executive functions, and specific working memory components.Results: Left and right epileptogenic foci resulted in impairment of verbal and nonverbal episodic memory (verbal memory deficit greater in left MTLE-HS than in right MTLE-HS). in addition, patients with left MTLE-HS were impaired in teaming paired associates, verbal fluency, and Trail Making. No differences were seen in the tests carried out to evaluate the working memory components (except visuospatial short-term memory in right MTLE-HS).Conclusion: in this study we did not detect reliable working memory impairment in patients with MTLE-HS with either a left or right focus in most tasks considered as tests of working memory components. (C) 2010 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, Epilepsy Div, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, Epilepsy Div, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAFIP
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent223-228
dc.identifierhttp://dx.doi.org/10.1016/j.yebeh.2010.04.021
dc.identifier.citationEpilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 18, n. 3, p. 223-228, 2010.
dc.identifier.doi10.1016/j.yebeh.2010.04.021
dc.identifier.issn1525-5050
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32689
dc.identifier.wosWOS:000280259500014
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEpilepsy & Behavior
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectWorking memoryen
dc.subjectEpisodic memoryen
dc.subjectSemantic memoryen
dc.subjectEpisodic bufferen
dc.subjectSequencing processen
dc.subjectMesial temporal lobe epilepsyen
dc.titleAssessment of working memory in patients with mesial temporal lobe epilepsy associated with unilateral hippocampal sclerosisen
dc.typeinfo:eu-repo/semantics/article
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