Morphological determinants of peripheral lung mechanical changes induced by capsaicin

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dc.contributor.authorDolhnikoff, M.
dc.contributor.authorSakae, R. S.
dc.contributor.authorSaldiva, PHN
dc.contributor.authorMartins, M. A.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:30:19Z
dc.date.available2016-01-24T12:30:19Z
dc.date.issued1997-04-01
dc.description.abstractWe studied the morphological elements associated with airway and pulmonary tissue responses to capsaicin in mechanically ventilated guinea pigs. Lungs were excised and frozen in liquid nitrogen 3 and 20 min after capsaicin infusion (1 or 100 mu g/kg i.v.). Using image analysis, we obtained contraction index (CI) and peribronchial edema area (CUFF) for both central (C) and peripheral airways (P). We also assessed alveolar size (mean linear intercepts, L-m and tissue distortion (standard deviation of the number of intercepts, SDI). Multiple regression analysis showed significant associations between pulmonary tissue resistance (R-ti and CUFFP (p < 0.001); pulmonary dynamic elastance and SDI (p = 0.002); and airway resistance and CUFFC (p < 0.0001). Our results suggest that increases in R-ti observed in guinea pigs after capsaicin infusion are primarily dependent on changes in the small airways, mainly peribronchiolar edema; the increase in lung elastance is related to distortion of parenchymal tissues; and large airway edema contributes significantly to airway resistance. (C) 1997 Elsevier Science B.V.en
dc.description.affiliationUniversidade Federal de São Paulo,FAC MED,DEPT MED,BR-01246903 São Paulo,BRAZIL
dc.description.affiliationUnifespUniversidade Federal de São Paulo,FAC MED,DEPT MED,BR-01246903 São Paulo,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent63-72
dc.identifierhttp://dx.doi.org/10.1016/S0034-5687(97)02526-7
dc.identifier.citationRespiration Physiology. Amsterdam: Elsevier B.V., v. 108, n. 1, p. 63-72, 1997.
dc.identifier.doi10.1016/S0034-5687(97)02526-7
dc.identifier.issn0034-5687
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/25710
dc.identifier.wosWOS:A1997XA56700006
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofRespiration Physiology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectneurokininsen
dc.subjectlung tissue resistanceen
dc.subjectimage analysisen
dc.titleMorphological determinants of peripheral lung mechanical changes induced by capsaicinen
dc.typeinfo:eu-repo/semantics/article
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