Association of the CYP17 gene polymorphism with risk for uterine leiomyoma in Brazilian women

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dc.contributor.authorVieira, Lucinda Coelho Esperança [UNIFESP]
dc.contributor.authorGomes, Mariano Tamura Vieira [UNIFESP]
dc.contributor.authorCastro, Rodrigo de Aquino [UNIFESP]
dc.contributor.authorNogueira-de-Souza, Naiara Corrêa [UNIFESP]
dc.contributor.authorSilva, Ismael Dale Cotrim Guerreiro da [UNIFESP]
dc.contributor.authorBaracat, Edmund Chada [UNIFESP]
dc.contributor.authorGirão, Manoel João Batista Castello [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:49:25Z
dc.date.available2016-01-24T13:49:25Z
dc.date.issued2008-01-01
dc.description.abstractBackground. Uterine leiomyoma is the most common pelvic tumor in women of reproductive age. It is well established that endogenous sex hormones are involved in disease pathogenesis, and polymorphisms in genes encoding enzymes which act in the metabolism of steroid hormones, such as that for cytochrome P450c17 enzyme (CYP17), may therefore play a role in fibroid genesis. Variations in this gene have been thought to influence the susceptibility to hormone-related diseases. A single nucleotide polymorphism (T -> C) [rs1042386] in promoter region of CYP17 may alter its transcription. the present study was conducted to investigate the association between this polymorphism and the presence of uterine leiomyoma in Brazilian women.Methods. Genotyping of CYP17 was performed in 121 uterine fibroid patients and 120 unaffected women, using polymerase chain reaction and restriction fragment-length polymorphism analysis.Results. No significant difference in the CYP17 genotype distribution was noted between cases and controls (p=0.165). Conclusion. These findings suggest that the CYP17 gene polymorphism studied is unlikely to be associated with risk for uterine leiomyoma in Brazilian women.en
dc.description.affiliationUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent373-377
dc.identifierhttp://dx.doi.org/10.1080/09513590802131830
dc.identifier.citationGynecological Endocrinology. New York: Informa Healthcare, v. 24, n. 7, p. 373-377, 2008.
dc.identifier.doi10.1080/09513590802131830
dc.identifier.issn0951-3590
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30318
dc.identifier.wosWOS:000257791800005
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofGynecological Endocrinology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.subjectuterine leiomyomaen
dc.subjectuterine fibroidsen
dc.subjecthormone metabolismen
dc.subjectCYP17en
dc.subjectpolymorphismen
dc.subjectsingle nucleotide polymorphismen
dc.titleAssociation of the CYP17 gene polymorphism with risk for uterine leiomyoma in Brazilian womenen
dc.typeinfo:eu-repo/semantics/article
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