Concentration of sulfated glycosaminoglycans in the mammary tissue of female rats with the aging and about hormonal influence

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dc.citation.issue1
dc.citation.volume34
dc.contributor.authorTorres, Sueli M. P. S. [UNIFESP]
dc.contributor.authorNader, Helena B. [UNIFESP]
dc.contributor.authorSimoes, Ricardo S. [UNIFESP]
dc.contributor.authorBaracat, Edmund C. [UNIFESP]
dc.contributor.authorSimoes, Manuel de J. [UNIFESP]
dc.contributor.authorFuchs, Luiz F. P. [UNIFESP]
dc.contributor.authorSoares-, Jose Maria, Jr. [UNIFESP]
dc.contributor.authorGomes, Regina Celia T. [UNIFESP]
dc.coverageAbingdon
dc.date.accessioned2020-07-02T18:52:00Z
dc.date.available2020-07-02T18:52:00Z
dc.date.issued2018
dc.description.abstractIt was to evaluate the concentration of sulfate glycosaminoglycans (GAG) in mammary tissue of the young and adult female rats and ovariectomized females rats after hormonal stimulation. For this purpose, 60 female rats were divided into six groups with 10 animals/each: nonovariectomized groups: G1 (5 months), and G2 (15 months) and ovariectomized groups: OG (vehicle)en
dc.description.abstractEG: (estradiol, 7 days of treatment), PG (progesterone acetate, 23 days of treatment) and EPG: (estradiol (7 days of treatment) and next progesterone acetate (23 days of treatment). Twenty-four hours after the last treatment, all animals were euthanized, the mammary tissue removed, processed for biochemical evaluation and quantification of the GAG. The comparison between groups showed that the concentration dermatan sulfate (DS) G1 was lower compared to G2, OG, EG (p < .05) and G2 was lower compared to OG (p < .05), and OG was higher compared to EG, GP, EPG (p < .05)en
dc.description.abstractand heparan sulfate (HS) G1 was higher compared to G2 (p < .05), and G2 was higher compared to OG, EP, PG and EPG (p < .05). These changes in the extracellular matrix might explain, at least in part, hormonal influence about sulfated glycosaminoglycans in response to physiological state/age, and in response to hormonal treatment in the mammary tissues.en
dc.description.affiliationUniv Fed Sao Paulo, Histol & Struct Biol Div, Dept Morphol & Genet, Rua Botucatu 740, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biochem, Mol Biol Div, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Gynecol Div, Dept Obstet & Gynecol, Hosp Clin,Fac Med, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Gynecol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Histol & Struct Biol Div, Dept Morphol & Genet, Rua Botucatu 740, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biochem, Mol Biol Div, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Gynecol Div, Dept Obstet & Gynecol, Hosp Clin,Fac Med, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Gynecol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent64-68
dc.identifierhttp://dx.doi.org/10.1080/09513590.2017.1336218
dc.identifier.citationGynecological Endocrinology. Abingdon, v. 34, n. 1, p. 64-68, 2018.
dc.identifier.doi10.1080/09513590.2017.1336218
dc.identifier.issn0951-3590
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53812
dc.identifier.wosWOS:000428120800015
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofGynecological Endocrinology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectMammary tissueen
dc.subjectsulfated glycosaminoglycansen
dc.subjectestradiolen
dc.subjectprogesteroneen
dc.titleConcentration of sulfated glycosaminoglycans in the mammary tissue of female rats with the aging and about hormonal influenceen
dc.typeinfo:eu-repo/semantics/article
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