Extracellular vesicles: structure, function, and potential clinical uses in renal diseases

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dc.contributor.authorBorges, Fernanda Teixeira [UNIFESP]
dc.contributor.authorReis, L. A. [UNIFESP]
dc.contributor.authorSchor, Nestor [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Cruzeiro Sul
dc.date.accessioned2016-01-24T14:34:28Z
dc.date.available2016-01-24T14:34:28Z
dc.date.issued2013-10-01
dc.description.abstractInterest in the role of extracellular vesicles in various diseases including cancer has been increasing. Extracellular vesicles include microvesicles, exosomes, apoptotic bodies, and argosomes, and are classified by size, content, synthesis, and function. Currently, the best characterized are exosomes and microvesicles. Exosomes are small vesicles (40- 100 nm) involved in intercellular communication regardless of the distance between them. They are found in various biological fluids such as plasma, serum, and breast milk, and are formed from multivesicular bodies through the inward budding of the endosome membrane. Microvesicles are 100-1000 nm vesicles released from the cell by the outward budding of the plasma membrane. the therapeutic potential of extracellular vesicles is very broad, with applications including a route of drug delivery and as biomarkers for diagnosis. Extracellular vesicles extracted from stem cells may be used for treatment of many diseases including kidney diseases. This review highlights mechanisms of synthesis and function, and the potential uses of wellcharacterized extracellular vesicles, mainly exosomes, with a special focus on renal functions and diseases.en
dc.description.affiliationUniv Fed Paulista, Dept Med, Div Nefrol, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliationUniv Cruzeiro Sul, Programa Posgrad Ciencias Saude Ciencias Biol & S, São Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Paulista, Dept Med, Div Nefrol, Escola Paulista Med, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent824-830
dc.identifierhttp://dx.doi.org/10.1590/1414-431X20132964
dc.identifier.citationBrazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 46, n. 10, p. 824-830, 2013.
dc.identifier.doi10.1590/1414-431X20132964
dc.identifier.fileS0100-879X2013001000824.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2013001000824
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36785
dc.identifier.wosWOS:000326015700002
dc.language.isoeng
dc.publisherAssoc Bras Divulg Cientifica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectExtracellular vesiclesen
dc.subjectCell biologyen
dc.subjectKidney diseasesen
dc.subjectDiagnosisen
dc.subjectTreatmenten
dc.titleExtracellular vesicles: structure, function, and potential clinical uses in renal diseasesen
dc.typeinfo:eu-repo/semantics/article
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