Influence of blood viscosity to cerebral blood flow in older humans compared to young subjects

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dc.contributor.authorSantos-Galduroz, Ruth F.
dc.contributor.authorBueno, Orlando F. A. [UNIFESP]
dc.contributor.authorYamaga, Lilian I.
dc.contributor.authorArmani, Fernanda [UNIFESP]
dc.contributor.authorGalduroz, Jose Carlos F. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Estadual Paulista
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.contributor.institutionHosp Israelita Ezrah
dc.contributor.institutionRes Inst Albert Einstein
dc.date.accessioned2016-01-24T14:17:42Z
dc.date.available2016-01-24T14:17:42Z
dc.date.issued2012-01-01
dc.description.abstractObjective: Since blood viscosity (BV) is one of the most important factors determining blood flow, this study aimed to investigate the possible correlation between increased blood viscosity and reduction of regional cerebral blood flow (rCBF) in healthy ageing.Methods: Male subjects were distributed in two groups: young, aged 20-30 (27 volunteers), or elderly, aged 60-70 (50 volunteers). Whole blood viscosity was obtained with a Wells-Brookfield Cone/Plate Viscometer. Cerebral blood flow was analysed by means of single photon emission computed tomography (SPECT).Results: the mean BV values were 3.28 +/- 0.43 mPa in the group of young volunteers and 4.33 +/- 0.73 mPa in the group of elderly volunteers (t = -6.9, p < 0.0001). the elderly had a lower blood flow than the young in the following regions: bilateral parietal; temporal-parietal and temporal of the left hemisphere. Pearson's correlation between BV and rCBF showed a good inverse correlation when the BV was above 3.95 +/- 0.83 mPa.Conclusions: Our results point to a close relationship between the two parameters analysed, BV and rCBF. the impairment in rCBF observed in the elderly volunteers might be due to an increase in BV, among other factors.Significance: These findings suggest interesting possibilities for the treatment/prevention of brain ageing. (C) 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, UNIFESP, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Biosci, Rio Claro, SP, Brazil
dc.description.affiliationUniv Fed ABC, Ctr Math Comp & Cognit, Santo Andre, SP, Brazil
dc.description.affiliationHosp Israelita Ezrah, São Paulo, SP, Brazil
dc.description.affiliationRes Inst Albert Einstein, São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UNIFESP, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent117-120
dc.identifierhttp://dx.doi.org/10.1016/j.clinph.2011.05.025
dc.identifier.citationClinical Neurophysiology. Clare: Elsevier B.V., v. 123, n. 1, p. 117-120, 2012.
dc.identifier.doi10.1016/j.clinph.2011.05.025
dc.identifier.issn1388-2457
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34449
dc.identifier.wosWOS:000298324800016
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofClinical Neurophysiology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectCerebral blood flowen
dc.subjectBlood viscosityen
dc.subjectAgeingen
dc.titleInfluence of blood viscosity to cerebral blood flow in older humans compared to young subjectsen
dc.typeinfo:eu-repo/semantics/article
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