Fluoride Induces Apoptosis in Mammalian Cells: In Vitro and In Vivo Studies

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dc.contributor.authorRibeiro, Daniel Araki [UNIFESP]
dc.contributor.authorCardoso, Caroline Margonato [UNIFESP]
dc.contributor.authorYujra, Veronica Quispe [UNIFESP]
dc.contributor.authorViana, Milena de Barros [UNIFESP]
dc.contributor.authorAguiar, Odair [UNIFESP]
dc.contributor.authorPisani, Luciana Pellegrini [UNIFESP]
dc.contributor.authorOshima, Celina Tizuko Fujiyama [UNIFESP]
dc.date.accessioned2019-08-19T11:48:27Z
dc.date.available2019-08-19T11:48:27Z
dc.date.issued2017
dc.description.abstractApoptosis is genetically programmed cell death, an irreversible process of cell senescence with characteristic features different from other cellular mechanisms of death such as necrosis. In the last years, apoptosis has been extensively studied in the scientific literature, because it has been established that apoptosis plays a crucial role following the time course of chronic degenerative diseases, such as cancer. Thus, several researchers have strugged to detect what chemical agents are able to inter fere with the apoptotic process. Thus, the purpose of this literature review is to assess if fluoride induces apoptosis in mammalian cells using in vivo and in vitro test systems. Certain mammalian cell types such as oral cells, blood and brain were exetensively investigateden
dc.description.abstractthe results showed that fluoride is able to induce apoptosis in both intrinsinc and extrinsic pathways. Moreover, other cells types have been poorly investigated such as bone, kidney and reproductive cells with conflicting results so far. Therefore, this area needs further investigation for the safety of human populations exposed to fluoride in a chronic way, as for example in developing countries.en
dc.description.affiliationUniv Fed São Paulo, UNIFESP, Dept Biosci, São Paulo, Brazil
dc.description.affiliationUniv Fed São Paulo, UNIFESP, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnifespUniv Fed São Paulo, UNIFESP, Dept Biosci, São Paulo, Brazil
dc.description.affiliationUnifespUniv Fed São Paulo, UNIFESP, Dept Pathol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent4767-4777
dc.identifierhttps://dx.doi.org/10.21873/anticanres.11883
dc.identifier.citationAnticancer Research. Athens, v. 37, n. 9, p. 4767-4777, 2017.
dc.identifier.doi10.21873/anticanres.11883
dc.identifier.issn0250-7005
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/51256
dc.identifier.wosWOS:000412578200006
dc.language.isoeng
dc.publisherInt Inst Anticancer Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectFluorideen
dc.subjectApoptosisen
dc.subjectin vitro studiesen
dc.subjectin vivo studiesen
dc.subjectReviewen
dc.titleFluoride Induces Apoptosis in Mammalian Cells: In Vitro and In Vivo Studiesen
dc.typeinfo:eu-repo/semantics/review
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