Effects of corticosteroid, montelukast and iNOS inhibition on distal lung with chronic inflammation

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dc.contributor.authorRibas Souza, Flavia Castro
dc.contributor.authorGobbato, Nathalia Brandao
dc.contributor.authorMaciel, Rafaela Guerra
dc.contributor.authorPrado, Carla Maximo [UNIFESP]
dc.contributor.authorMartins, Milton Arruda
dc.contributor.authorLeick, Edna A.
dc.contributor.authorCalvo Tiberio, Iolanda F. L.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:31:08Z
dc.date.available2016-01-24T14:31:08Z
dc.date.issued2013-01-15
dc.description.abstractWe evaluated the effects of anti-iNOS (1400W - W) associated with leukotriene antagonist (montelukast - M) or corticosteroid (dexamethasone - D) on distal lung of guinea pigs (GP) with chronic pulmonary inflammation.Methods: GP were inhaled with ovalbumin (OVA-2x/week/4 weeks), treated with M (OVAM), D (OVAD) and/or W (OVAW, OVADW, OVAMW) and distal lungs were evaluated by morphometry.Results: Isolated treatments were not sufficient to reduce all parameters. in OVADW, all parameters were reduced with greater reduction in elastic fibers, TIMP-1, IL-4, IL-5, IFN-gamma and PGF2-alpha compared with OVAD (p<0.05). OVAMW potentiated the reduction of actin, elastic fibers, TIMP-1, IL-4, IL-5, TGFbeta, IFN-gamma, iNOS, and PGF2-alpha to a greater extent than OVAM (p<0.05). A reduction of TIMP-1, IL-4, IL-5, TGF-beta, IFN-gamma and iNOS was observed in OVADW compared with OVAMW (p<0.05).Conclusions: Although anti-iNOS paired with montelukast or dexamethasone yields better results than isolated treatments, the most effective pairing for controlling inflammation, oxidative stress and remodeling in this asthma model was found to be corticosteroids and anti-iNOS. (C) 2012 Published by Elsevier B.V.en
dc.description.affiliationUniv São Paulo, Sch Med, BR-01246903 São Paulo, Brazil
dc.description.affiliationFed Univ São Paulo UNIFESP, BR-09972270 Diadema, SP, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, BR-09972270 Diadema, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipLIM-20 FMUSP, Brazil
dc.format.extent435-445
dc.identifierhttp://dx.doi.org/10.1016/j.resp.2012.08.015
dc.identifier.citationRespiratory Physiology & Neurobiology. Amsterdam: Elsevier B.V., v. 185, n. 2, p. 435-445, 2013.
dc.identifier.doi10.1016/j.resp.2012.08.015
dc.identifier.issn1569-9048
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35879
dc.identifier.wosWOS:000314481200032
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofRespiratory Physiology & Neurobiology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectAsthmaen
dc.subjectChronic airway inflammationen
dc.subjectExperimental models of asthmaen
dc.subjectiNOSen
dc.subjectCorticosteroidsen
dc.subjectLeukotriene antagonistsen
dc.titleEffects of corticosteroid, montelukast and iNOS inhibition on distal lung with chronic inflammationen
dc.typeinfo:eu-repo/semantics/article
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