Activity of garenoxacin, an investigational des-F(6)-quinolone, tested against pathogens from community-acquired respiratory tract infections, including those with elevated or resistant-level fluoroquinolone MIC values

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dc.contributor.authorJones, Ronald N.
dc.contributor.authorFritsche, Thomas R.
dc.contributor.authorSader, Helio S.
dc.contributor.authorStilwell, Matthew G.
dc.contributor.institutionJMI Labs
dc.contributor.institutionTufts Univ
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:48:38Z
dc.date.available2016-01-24T13:48:38Z
dc.date.issued2007-05-01
dc.description.abstractGarenoxacin, a novel des-F(6)-quinolone, was tested against 40423 pathogenic isolates associated with community-acquired respiratory tract infections (CA-RTIs). the strains included Streptococcus pneumoniae (18887), Haemophilus influenzae (15555), and Moraxella catarrhalis (5981), each isolated from a significant infection monitored by the SENTRY Antimicrobial Surveillance Program (1999-2005; North America, Latin America, and Europe). All tests were performed by reference broth microdilution methods for garenoxacin and 19 comparison agents. the garenoxacin MIC90 and percentage (%) of strains inhibited at <= 1 mu g/mL (proposed susceptible breakpoint) were S. pneumoniae (0.06 mu g/mL, > 99.9% susceptible), H. influenzae (<= 0.03 mu g/mL, > 99.9%,), and M. catarrhalis (<= 0.03 mu g/mL, 100.0%). the garenoxacin potency versus the pneumococci was 16- to 32-fold greater than levofloxacin or ciprofloxacin and 2-fold superior to moxifloxacin (MIC90, 0.12 mu g/mL). Resistances to other classes of antimicrobials did not adversely influence garenoxacin MIC results. Ciprofloxacin- or levofloxacin-resistant (MIC90, >= 4 mu g/mL) S. pneumoniae had higher garenoxacin MIC90 values (1 mu g/mL), but 90.6% to 97.5% of strains remained susceptible. Strains of all 3 monitored pathogens with mutations in the quinolone resistance determining region (QRDR) had higher garenoxacin MIC results, with >= 3 to 4 QRDR mutations required to elevate garenoxacin MIC values to 2 mu g/mL. in conclusion, garenoxacin possesses a potent activity against pneumococci, H.. influenzae, and M. catarrhalis strains worldwide, at a level significantly greater than the available tested agents in the fluoroquinolone class (ciprofloxacin, levofloxacin, and moxifloxacin). Only 13 and 4 isolates (0.07% and 0.03%) of S. pneumoniae and H. influenzae, respectively, had a garenoxacin MIC at >= 2 mu g/mL, thus, making this new respiratory antipneumococcal quinolone an attractive candidate for the therapy of coil temporary CA-RTI (bronchitis, pneumonia, and sinusitis). (c) 2007 Elsevier Inc. All rights reserved.en
dc.description.affiliationJMI Labs, N Liberty, IA 52317 USA
dc.description.affiliationTufts Univ, Sch Med, Boston, MA 02111 USA
dc.description.affiliationUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent9-17
dc.identifierhttp://dx.doi.org/10.1016/j.diagmicrobio.2007.01.020
dc.identifier.citationDiagnostic Microbiology and Infectious Disease. New York: Elsevier B.V., v. 58, n. 1, p. 9-17, 2007.
dc.identifier.doi10.1016/j.diagmicrobio.2007.01.020
dc.identifier.issn0732-8893
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29700
dc.identifier.wosWOS:000246748000002
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofDiagnostic Microbiology and Infectious Disease
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectgarenoxacinen
dc.subjectS. pneumoniaeen
dc.subjectH. influenzaeen
dc.subjectM. catarrhalisen
dc.subjectresistanceen
dc.titleActivity of garenoxacin, an investigational des-F(6)-quinolone, tested against pathogens from community-acquired respiratory tract infections, including those with elevated or resistant-level fluoroquinolone MIC valuesen
dc.typeinfo:eu-repo/semantics/article
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