Feline sporotrichosis due to Sporothrix brasiliensis: an emerging animal infection in São Paulo, Brazil

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dc.contributor.authorMontenegro, Hildebrando
dc.contributor.authorRodrigues, Anderson Messias [UNIFESP]
dc.contributor.authorDias, Maria Adelaide Galvao
dc.contributor.authorSilva, Elisabete Aparecida da
dc.contributor.authorBernardi, Fernanda
dc.contributor.authorCamargo, Zoilo Pires de [UNIFESP]
dc.contributor.institutionZoonosis Control Ctr São Paulo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:38:11Z
dc.date.available2016-01-24T14:38:11Z
dc.date.issued2014-11-19
dc.description.abstractBackground: Sporotrichosis is a mycotic infectious disease that is generally acquired by traumatic inoculation of contaminated materials especially from plant debris or through bites and scratches from diseased animals, such as domestic cats. It affects the skin, lymphatic system, and other organs in the warm-blooded host. Etiological agents are embedded in the plant-associated order Ophiostomatales. With essential differences between possible outbreak sources and ecological niche, host-environment interactions are classic determinants of risk factors for disease acquisition. Sporotrichosis outbreaks with zoonotic transmission, such as those that are ongoing in southern and southeastern Brazil, have highlighted the threat of cross-species pathogen transmission. Sporothrix brasiliensis has emerged as a human threat owing to the intimate contact pattern between diseased cats and humans in endemic areas.Results: We describe the recent emergence of feline sporotrichosis in the metropolitan region of São Paulo, Brazil, with an overwhelming occurrence of S. brasiliensis as the etiological agent. A phylogenetic and a haplotype approach were used to investigate the origin of this epidemic and the impact of feline transmission on genetic diversity. During the last 3-year period, 163 cases of feline sporotrichosis were reported in São Paulo with proven S. brasiliensis culture. the haplotype diversity of feline S. brasiliensis isolates revealed the expansion of a clonal population with low genetic diversity. Haplotype analysis confirmed that isolates from São Paulo shared the haplotype originated in the long-lasting outbreak of cat-transmitted sporotrichosis in Rio de Janeiro, which differed from the haplotype circulating in the Rio Grande do Sul epidemic.Conclusions: the fast spread of sporotrichosis in a short period of time highlights the potential for outbreaks and suggests that the mycosis may affect an urban population with a high concentration of susceptible felines. the feline sporotrichosis epidemic shows no signs of slowing, and this epidemiological pattern may require specific public health strategies to control future outbreaks.en
dc.description.affiliationZoonosis Control Ctr São Paulo, COVISA SMS PMSP, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, Div Cell Biol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, Div Cell Biol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDFAPESP: 2011/07350-1
dc.description.sponsorshipIDFAPESP: 2009/54024-2
dc.description.sponsorshipIDCNPq: 472600/2011-7
dc.description.sponsorshipIDCNPq: 472169/2012-2
dc.format.extent10
dc.identifierhttp://dx.doi.org/10.1186/s12917-014-0269-5
dc.identifier.citationBmc Veterinary Research. London: Biomed Central Ltd, v. 10, 10 p., 2014.
dc.identifier.doi10.1186/s12917-014-0269-5
dc.identifier.fileWOS000347013400001.pdf
dc.identifier.issn1746-6148
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38462
dc.identifier.wosWOS:000347013400001
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofBmc Veterinary Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSporotrichosisen
dc.subjectFelineen
dc.subjectSporothrix brasiliensisen
dc.subjectZoonosisen
dc.subjectEmerging infectious diseasesen
dc.subjectEpidemiologyen
dc.subjectCaten
dc.subjectSporothrix schenckiien
dc.subjectMycosisen
dc.subjectOutbreaken
dc.titleFeline sporotrichosis due to Sporothrix brasiliensis: an emerging animal infection in São Paulo, Brazilen
dc.typeinfo:eu-repo/semantics/article
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